Factors Associated with Lumbar Puncture Participation in Alzheimer's Disease Research

Cerebrospinal fluid (CSF) provides insight into the spectrum of Alzheimer's disease (AD) pathology. While lumbar punctures (LPs) for CSF collection are generally considered safe procedures, many participants remain hesitant to participate in research involving LPs. To explore factors associated...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2020-01, Vol.77 (4), p.1559-1567
Main Authors: Blazel, Madeleine M, Lazar, Karen K, Van Hulle, Carol A, Ma, Yue, Cole, Aleshia, Spalitta, Alice, Davenport-Sis, Nancy, Bendlin, Barbara B, Wahoske, Michelle, Illingworth, Chuck, Gleason, Carey E, Edwards, Dorothy F, Blazel, Hanna, Asthana, Sanjay, Johnson, Sterling C, Carlsson, Cynthia M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - metabolism
Alzheimer Disease - psychology
Alzheimer's disease
Biomarkers - metabolism
Biomedical Research - trends
Body mass
Body mass index
Body size
Cerebrospinal fluid
Cognition
Cognitive ability
Dementia disorders
Demographic variables
Education
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Minority & ethnic groups
Neurodegenerative diseases
Participation
Patient Participation - psychology
Patient Participation - trends
Race
Regression analysis
Regression models
Research facilities
Spinal Puncture - psychology
Spinal Puncture - trends
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Summary:Cerebrospinal fluid (CSF) provides insight into the spectrum of Alzheimer's disease (AD) pathology. While lumbar punctures (LPs) for CSF collection are generally considered safe procedures, many participants remain hesitant to participate in research involving LPs. To explore factors associated with participant willingness to undergo a research LP at baseline and follow-up research study visit. We analyzed data from 700 participants with varying cognition (unimpaired, mild cognitive impairment, and dementia) in the Wisconsin Alzheimer's Disease Research Center. We evaluated the relationship of demographic variables (age, sex, race, ethnicity, and years of education) and clinical variables (waist-to-hip ratio, body mass index, AD parental history, cognitive diagnosis) on decision to undergo baseline LP1. We evaluated the relationship of prior LP1 experience (procedure success and adverse events) with the decision to undergo follow-up LP2. The strongest predictors were incorporated into regression models. Over half of eligible participants opted into both baseline and follow-up LP. Participants who underwent LP1 had higher mean education than those who declined (p = 0.020). White participants were more likely to choose to undergo LP1 (p 
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-200394