Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study

Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study...

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Bibliographic Details
Published in:Journal of epidemiology 2006-09, Vol.16 (5), p.177-184
Main Authors: Cui, Renzhe, Iso, Hiroyasu, Toyoshima, Hideaki, Date, Chigusa, Yamamoto, Akio, Kikuchi, Shogo, Kondo, Takaaki, Watanabe, Yoshiyuki, Koizumi, Akio, Inaba, Yutaka, Tamakoshi, Akiko
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Cohort Studies
Comorbidity
Coronary Disease - epidemiology
Coronary Disease - mortality
Educational Status
Female
Health Behavior
Human Development
Humans
Japan
Marital Status
Menarche
Menopause
Middle Aged
Original
Postmenopause
Stroke - epidemiology
Stroke - mortality
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Summary:Early menopause is associated with increased risk of coronary heart disease in Caucasian women. However, this association has not been examined in Asian women. We conducted a 10-year cohort study of 37,965 Japanese post-menopausal women aged 40-79 years in the Japan Collaborative Cohort (JACC) Study. Causes of death were determined based on the International Classification of Disease. There were 487 mortality of stroke and 178 mortality of coronary heart disease. Late menarche or early menopause, or shorter duration of reproductive period was not associated with risk of mortality from coronary heart disease. However, compared with women with age at menarche < or =13 years, those with age at menarche > or =17 years tended to have increased risk of mortality from stroke: the multivariable hazard ratio was 1.32 (95% confidence interval [CI]: 0.93-1.87, p = 0.10). Compared with women with age at menopause of > or =49 years, those with age at menopause of
ISSN:0917-5040
1349-9092
DOI:10.2188/jea.16.177