The influence of topical use of tranexamic acid in reducing blood loss on early operation for thoracolumbar burst fracture: a randomized double-blinded controlled study

Purpose To investigate the safety and efficacy of topical use of tranexamic acid (TXA) on early operation for thoracolumbar burst fracture (TBF). Methods Patients with acute TBF requiring early decompression were prospectively collected. The enrolled patients were randomly assigned to TXA and contro...

Full description

Saved in:
Bibliographic Details
Published in:European spine journal 2021-10, Vol.30 (10), p.3074-3080
Main Authors: Shen, Jieliang, Yang, Zhengyang, Fu, Mengyu, Hao, Jie, Jiang, Wei
Format: Article
Language:English
Subjects:
Antifibrinolytic agents
Blood transfusion
Blood transfusions
Decompression
Demography
Hemoglobin
Medicine
Medicine & Public Health
Neurosurgery
Original
Original Article
Patients
Surgical Orthopedics
Wounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To investigate the safety and efficacy of topical use of tranexamic acid (TXA) on early operation for thoracolumbar burst fracture (TBF). Methods Patients with acute TBF requiring early decompression were prospectively collected. The enrolled patients were randomly assigned to TXA and control group, in which wound surface was soaked with TXA or the same volume of normal saline for 5 min after wound incision, respectively. The total blood loss (TBL), intraoperative blood loss (IBL), postoperative blood loss (PBL), hemoglobin (HGB) levels on preoperatively (pre-op) and postoperatively, and amount of allogenic blood transfusion were recorded. Furthermore, the general information was also compared between groups. Results There were 39 and 37 patients enrolled in TXA and control group for final analysis. The demographics data showed no significant difference between groups ( P  > 0.05), but operation time and IBL were significantly decreased in TXA group ( P  
ISSN:0940-6719
1432-0932
DOI:10.1007/s00586-020-06626-x