Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth

• Published in: The Journal of pediatrics 2020-12, Vol.227, p.199-203.e1
• Main Authors: Czeck, Madeline A., Northrop, Elise F., Evanoff, Nicholas G., Dengel, Donald R., Rudser, Kyle D., Kelly, Aaron S., Ryder, Justin R.
• Format: Article
• Language: English
• Subjects: Adolescent; Apolipoproteins - blood; arterial stiffness; arterial structure; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Carotid Intima-Media Thickness; Child; Female; Humans; Male; pediatrics; Pulse Wave Analysis; pulse wave velocity; Risk Assessment; Ultrasonography, Interventional; Vascular Stiffness
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2020.08.017

To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents. A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins. There was a significant positive association between pulse wave velocity and apolipoproteins: AI (0.015 m/s/10 μg/mL [CI 0.005-0.026], P = .003), AII (0.036 m/s/10 μg/mL [0.017-0.056], P