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Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth
To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents. A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via hum...
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| Published in: | The Journal of pediatrics 2020-12, Vol.227, p.199-203.e1 |
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| container_end_page | 203.e1 |
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| container_title | The Journal of pediatrics |
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| creator | Czeck, Madeline A. Northrop, Elise F. Evanoff, Nicholas G. Dengel, Donald R. Rudser, Kyle D. Kelly, Aaron S. Ryder, Justin R. |
| description | To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents.
A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins.
There was a significant positive association between pulse wave velocity and apolipoproteins: AI (0.015 m/s/10 μg/mL [CI 0.005-0.026], P = .003), AII (0.036 m/s/10 μg/mL [0.017-0.056], P |
| doi_str_mv | 10.1016/j.jpeds.2020.08.017 |
| format | article |
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A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins.
There was a significant positive association between pulse wave velocity and apolipoproteins: AI (0.015 m/s/10 μg/mL [CI 0.005-0.026], P = .003), AII (0.036 m/s/10 μg/mL [0.017-0.056], P < .001), B100 (0.009 m/s/10 μg/mL [0.002-0.016], P = .012), E (0.158 m/s/10 μg/mL [0.080-0.235], P < .001), and CIII:CII (0.033/μg/mL [0.014-0.052], P < .001). After we added body fat percent to the models, pulse wave velocity (PWV) remained positively associated with greater levels of apolipoproteins: AI, AII, B100, E, and CIII:CII. Both with and without the adjustment for body fat percent, there were no significant associations between any apolipoprotein and carotid intima-media thickness. There were no significant interactions between Tanner stage and apolipoproteins.
These findings suggest that greater levels of apolipoprotein AII, E, and CIII:CII are associated with increased arterial stiffness in children and adolescents, both with and without adjusting for percent body fat. These specific apolipoproteins may be useful as biomarkers of cardiovascular risk.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2020.08.017</identifier><identifier>PMID: 32795477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Apolipoproteins - blood ; arterial stiffness ; arterial structure ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Carotid Intima-Media Thickness ; Child ; Female ; Humans ; Male ; pediatrics ; Pulse Wave Analysis ; pulse wave velocity ; Risk Assessment ; Ultrasonography, Interventional ; Vascular Stiffness</subject><ispartof>The Journal of pediatrics, 2020-12, Vol.227, p.199-203.e1</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-28f8f810e405cdf966284cf9dcf423ac6a69fd56c4bff21a9544eaefc4e5fe963</citedby><cites>FETCH-LOGICAL-c459t-28f8f810e405cdf966284cf9dcf423ac6a69fd56c4bff21a9544eaefc4e5fe963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32795477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Czeck, Madeline A.</creatorcontrib><creatorcontrib>Northrop, Elise F.</creatorcontrib><creatorcontrib>Evanoff, Nicholas G.</creatorcontrib><creatorcontrib>Dengel, Donald R.</creatorcontrib><creatorcontrib>Rudser, Kyle D.</creatorcontrib><creatorcontrib>Kelly, Aaron S.</creatorcontrib><creatorcontrib>Ryder, Justin R.</creatorcontrib><title>Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents.
A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins.
There was a significant positive association between pulse wave velocity and apolipoproteins: AI (0.015 m/s/10 μg/mL [CI 0.005-0.026], P = .003), AII (0.036 m/s/10 μg/mL [0.017-0.056], P < .001), B100 (0.009 m/s/10 μg/mL [0.002-0.016], P = .012), E (0.158 m/s/10 μg/mL [0.080-0.235], P < .001), and CIII:CII (0.033/μg/mL [0.014-0.052], P < .001). After we added body fat percent to the models, pulse wave velocity (PWV) remained positively associated with greater levels of apolipoproteins: AI, AII, B100, E, and CIII:CII. Both with and without the adjustment for body fat percent, there were no significant associations between any apolipoprotein and carotid intima-media thickness. There were no significant interactions between Tanner stage and apolipoproteins.
These findings suggest that greater levels of apolipoprotein AII, E, and CIII:CII are associated with increased arterial stiffness in children and adolescents, both with and without adjusting for percent body fat. These specific apolipoproteins may be useful as biomarkers of cardiovascular risk.</description><subject>Adolescent</subject><subject>Apolipoproteins - blood</subject><subject>arterial stiffness</subject><subject>arterial structure</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>pediatrics</subject><subject>Pulse Wave Analysis</subject><subject>pulse wave velocity</subject><subject>Risk Assessment</subject><subject>Ultrasonography, Interventional</subject><subject>Vascular Stiffness</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9Uctu1EAQHCEQWQJfgIR85GLT8_DYPoAUrcJDihQpwIHTaHbcw_Yy6zEz9iL-Jt-SL8NhQwQX1Ic-dFV1qYqx5xwqDly_2lW7EftcCRBQQVsBbx6wFYeuKXUr5UO2AhCilKrRJ-xJzjsA6BTAY3YiRdPVqmlW7PIKg50oDnlLYxF9cTbGQGMcU5yQhlz8oGlbfJw3LtBAzoZibVNP8WCzm4NNxRXlbzfXNNxcf4nztH3KHnkbMj6726fs89vzT-v35cXluw_rs4vSqbqbStH6ZTiggtr1vtNatMr5rndeCWmdtrrzfa2d2ngvuF3cKrToncLaY6flKXtz1B3nzR57h8OUbDBjor1NP020ZP69DLQ1X-PBNLrVnNeLwMs7gRS_z5gns6fsMAQ7YJyzEUoq1XAumwUqj1CXYs4J_f0bDua2CrMzv6swt1UYaM1SxcJ68bfDe86f7BfA6yMAl5wOhMlkRzg47Cmhm0wf6b8PfgGO6qBg</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Czeck, Madeline A.</creator><creator>Northrop, Elise F.</creator><creator>Evanoff, Nicholas G.</creator><creator>Dengel, Donald R.</creator><creator>Rudser, Kyle D.</creator><creator>Kelly, Aaron S.</creator><creator>Ryder, Justin R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201201</creationdate><title>Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth</title><author>Czeck, Madeline A. ; Northrop, Elise F. ; Evanoff, Nicholas G. ; Dengel, Donald R. ; Rudser, Kyle D. ; Kelly, Aaron S. ; Ryder, Justin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-28f8f810e405cdf966284cf9dcf423ac6a69fd56c4bff21a9544eaefc4e5fe963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Apolipoproteins - blood</topic><topic>arterial stiffness</topic><topic>arterial structure</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>pediatrics</topic><topic>Pulse Wave Analysis</topic><topic>pulse wave velocity</topic><topic>Risk Assessment</topic><topic>Ultrasonography, Interventional</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Czeck, Madeline A.</creatorcontrib><creatorcontrib>Northrop, Elise F.</creatorcontrib><creatorcontrib>Evanoff, Nicholas G.</creatorcontrib><creatorcontrib>Dengel, Donald R.</creatorcontrib><creatorcontrib>Rudser, Kyle D.</creatorcontrib><creatorcontrib>Kelly, Aaron S.</creatorcontrib><creatorcontrib>Ryder, Justin R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Czeck, Madeline A.</au><au>Northrop, Elise F.</au><au>Evanoff, Nicholas G.</au><au>Dengel, Donald R.</au><au>Rudser, Kyle D.</au><au>Kelly, Aaron S.</au><au>Ryder, Justin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>227</volume><spage>199</spage><epage>203.e1</epage><pages>199-203.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>To examine the association of apolipoproteins with arterial stiffness and carotid artery structure in children and adolescents.
A total of 338 children and adolescents (178 female) with a mean age 13.0 ± 2.8 years were examined. Apolipoproteins (AI, AII, B100, CII, CIII, and E) were measured via human apolipoprotein magnetic bead panel. Applanation tonometry determined pulse wave velocity and ultrasound imaging measured carotid intima-media thickness. Dual X-ray absorptiometry measured total body fat percent. Linear regression models were adjusted for Tanner stage, sex, and race with further adjustments for body fat percent. Linear regression models also examined the interaction between Tanner stage and apolipoproteins.
There was a significant positive association between pulse wave velocity and apolipoproteins: AI (0.015 m/s/10 μg/mL [CI 0.005-0.026], P = .003), AII (0.036 m/s/10 μg/mL [0.017-0.056], P < .001), B100 (0.009 m/s/10 μg/mL [0.002-0.016], P = .012), E (0.158 m/s/10 μg/mL [0.080-0.235], P < .001), and CIII:CII (0.033/μg/mL [0.014-0.052], P < .001). After we added body fat percent to the models, pulse wave velocity (PWV) remained positively associated with greater levels of apolipoproteins: AI, AII, B100, E, and CIII:CII. Both with and without the adjustment for body fat percent, there were no significant associations between any apolipoprotein and carotid intima-media thickness. There were no significant interactions between Tanner stage and apolipoproteins.
These findings suggest that greater levels of apolipoprotein AII, E, and CIII:CII are associated with increased arterial stiffness in children and adolescents, both with and without adjusting for percent body fat. These specific apolipoproteins may be useful as biomarkers of cardiovascular risk.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32795477</pmid><doi>10.1016/j.jpeds.2020.08.017</doi><oa>free_for_read</oa></addata></record> |
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| source | Elsevier |
| subjects | Adolescent Apolipoproteins - blood arterial stiffness arterial structure Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Carotid Intima-Media Thickness Child Female Humans Male pediatrics Pulse Wave Analysis pulse wave velocity Risk Assessment Ultrasonography, Interventional Vascular Stiffness |
| title | Relationship of Apolipoproteins with Subclinical Cardiovascular Risk in Youth |
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