The impact of hypertension on chronic kidney disease and end-stage renal disease is greater in men than women: a systematic review and meta-analysis

Hypertension (HTN) is an established risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Whether sex differences in the effect of HTN on CKD and ESRD incidence exist remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative impact o...

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Bibliographic Details
Published in:BMC nephrology 2020-11, Vol.21 (1), p.506-506, Article 506
Main Authors: Weldegiorgis, Misghina, Woodward, Mark
Format: Article
Language:English
Subjects:
Blood pressure
Cardiovascular diseases
Chronic kidney failure
Complications and side effects
Demographic aspects
Diabetes mellitus
Dialysis
End-stage renal disease
Gender differences
Hypertension
Kidney diseases
Medical research
Medicine, Experimental
Meta-analysis
Mortality
Nephrology
Patients
Risk factors
Sex
Sex differences
Sex factors in disease
Systematic review
Womens health
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Summary:Hypertension (HTN) is an established risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Whether sex differences in the effect of HTN on CKD and ESRD incidence exist remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative impact of HTN on CKD and ESRD risk in women compared with men. We systematically searched Embase and PubMed for cohort studies until 24 July 2020. Studies were selected if they reported a sex-specific association between systolic blood pressure (SBP) and CKD or ESRD. Random effects meta-analyses with inverse variance weighting were used to pool sex-specific relative risks (RRs) and the women-to-men ratio of RRs (the RRR) for incident CKD and ESRD. Data from six cohorts, including 2,382,712 individuals and 6856 incident CKD events, and 833 ESRD events, were included in the meta-analysis. The RR for incident CKD or ESRD associated with HTN (SBP ≥140 mmHg) versus ideal BP (SBP
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-020-02151-7