Temporal Leptin to Determine Cardiovascular and Metabolic Fate throughout the Life

Leptin links peripheral adiposity and the central nervous system (CNS) to regulate cardiometabolic physiology. Within the CNS, leptin receptor-expressing cells are a counterpart to circulating leptin, and leptin receptor-mediated neural networks modulate the output of neuroendocrine and sympathetic...

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Bibliographic Details
Published in:Nutrients 2020-10, Vol.12 (11), p.3256
Main Authors: Kim, Jae Geun, Lee, Byung Ju, Jeong, Jin Kwon
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity - drug effects
Amino acids
Amniotic fluid
Birth weight
Body Weight - drug effects
Cardiometabolic Risk Factors
Cardiovascular disease
Cardiovascular System - metabolism
Central nervous system
Central Nervous System - metabolism
Child development
Diabetes mellitus (non-insulin dependent)
DNA methylation
Female
Fetuses
Gestation
Gestational diabetes
Glucose
Homeostasis
Hormones
Humans
Hypertension
Infants
Insulin resistance
Leptin - blood
Longevity - drug effects
Male
Maternal Nutritional Physiological Phenomena
Metabolic disorders
Neural networks
Obesity
Offspring
Physiology
Pregnancy
Receptors, Leptin - blood
Review
Signal Transduction - drug effects
Temporal Lobe - metabolism
Womens health
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Summary:Leptin links peripheral adiposity and the central nervous system (CNS) to regulate cardiometabolic physiology. Within the CNS, leptin receptor-expressing cells are a counterpart to circulating leptin, and leptin receptor-mediated neural networks modulate the output of neuroendocrine and sympathetic nervous activity to balance cardiometabolic homeostasis. Therefore, disrupted CNS leptin signaling is directly implicated in the development of metabolic diseases, such as hypertension, obesity, and type 2 diabetes. Independently, maternal leptin also plays a central role in the development and growth of the infant during gestation. Accumulating evidence points to the dynamic maternal leptin environment as a predictor of cardiometabolic fate in their offspring as it is directly associated with infant metabolic parameters at birth. In postnatal life, the degree of serum leptin is representative of the level of body adiposity/weight, a driving factor for cardiometabolic alterations, and therefore, the levels of blood leptin through the CNS mechanism, in a large part, are a strong determinant for future cardiometabolic fate. The current review focuses on highlighting and discussing recent updates for temporal dissection of leptin-associated programing of future cardiometabolic fate throughout the entire life.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu12113256