Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration

[Display omitted] •We designed a transcatheter balloon-expandable resorbable vascular graft with support capacity.•After 2 months in vivo, grafts show native-like tissue reconstruction with endoluminal elastin.•The concept convenes regenerative grafting, minimally invasive delivery, and clinical ste...

Full description

Saved in:
Bibliographic Details
Published in:JACC. Basic to translational science 2020-11, Vol.5 (11), p.1095-1110
Main Authors: Duijvelshoff, Renee, Cabrera, Maria S., Sanders, Bart, Dekker, Sylvia, Smits, Anthal I.P.M., Baaijens, Frank P.T., Bouten, Carlijn V.C.
Format: Article
Language:English
Subjects:
elastin
Preclinical Research
regeneration
tissue engineering
transcatheter delivery
vascular graft
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •We designed a transcatheter balloon-expandable resorbable vascular graft with support capacity.•After 2 months in vivo, grafts show native-like tissue reconstruction with endoluminal elastin.•The concept convenes regenerative grafting, minimally invasive delivery, and clinical stenting. As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2020.09.005