The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about...

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Bibliographic Details
Published in:Genes 2020-10, Vol.11 (11), p.1273
Main Authors: Parker, Katherine, Erzurumluoglu, A Mesut, Rodriguez, Santiago
Format: Article
Language:English
Subjects:
Chromosomes
Chromosomes, Human, Y - genetics
Genetic Association Studies
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Haplotypes
Humans
Male
Models, Genetic
Molecular Epidemiology
Multifactorial Inheritance - genetics
Observations
Physiological aspects
Quantitative Trait Loci
Recombination, Genetic
Review
Sex Determination Processes
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Summary:The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11111273