The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about...

Full description

Saved in:
Bibliographic Details
Published in:Genes 2020-10, Vol.11 (11), p.1273
Main Authors: Parker, Katherine, Erzurumluoglu, A Mesut, Rodriguez, Santiago
Format: Article
Language:English
Subjects:
Chromosomes
Chromosomes, Human, Y - genetics
Genetic Association Studies
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Haplotypes
Humans
Male
Models, Genetic
Molecular Epidemiology
Multifactorial Inheritance - genetics
Observations
Physiological aspects
Quantitative Trait Loci
Recombination, Genetic
Review
Sex Determination Processes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993
cites cdi_FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993
container_end_page
container_issue 11
container_start_page 1273
container_title Genes
container_volume 11
creator Parker, Katherine
Erzurumluoglu, A Mesut
Rodriguez, Santiago
description The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.
doi_str_mv 10.3390/genes11111273
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7693691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A645157104</galeid><sourcerecordid>A645157104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993</originalsourceid><addsrcrecordid>eNpVkc1LAzEQxYMoWtSjVwl48bKaz03jQSiLtkLRSz14Ctk4aVd2NzXZFf3v3VIt-i4zMD_ezPAQOqPkinNNrpfQQqIbMcX30IgRxTMhmNz_0x-h05TeyCBBGCHyEB1xTrkaKzVCj4sV4BdcrGJoQgoN3OAJLkKzruETz4PrE_Yh4umwqKscnrS2_kqQcPA7atY3tsWLaKsunaADb-sEpz_1GD3f3y2KWTZ_mj4Uk3nmBJVdpqjklgOAB0ktU5qwMuc-z60vqfQOgAnrLFDgWjuQNqevAnRZKuI5aM2P0e3Wd92XDbw6aLtoa7OOVWPjlwm2Mv8nbbUyy_BhVK55rulgcPljEMN7D6kzTZUc1LVtIfTJMCEVG9Mx2aAXW3RpazBV68Pg6Da4meRCUqkoEQOVbSkXQ0oR_O4YSswmLPMvrIE___vBjv6Nhn8DXPmP-Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2457281801</pqid></control><display><type>article</type><title>The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Parker, Katherine ; Erzurumluoglu, A Mesut ; Rodriguez, Santiago</creator><creatorcontrib>Parker, Katherine ; Erzurumluoglu, A Mesut ; Rodriguez, Santiago</creatorcontrib><description>The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes11111273</identifier><identifier>PMID: 33137877</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Chromosomes ; Chromosomes, Human, Y - genetics ; Genetic Association Studies ; Genetic Variation ; Genetics, Population ; Genome-Wide Association Study ; Haplotypes ; Humans ; Male ; Models, Genetic ; Molecular Epidemiology ; Multifactorial Inheritance - genetics ; Observations ; Physiological aspects ; Quantitative Trait Loci ; Recombination, Genetic ; Review ; Sex Determination Processes</subject><ispartof>Genes, 2020-10, Vol.11 (11), p.1273</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993</citedby><cites>FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993</cites><orcidid>0000-0003-1322-8138 ; 0000-0001-6551-932X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693691/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693691/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,36990,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33137877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parker, Katherine</creatorcontrib><creatorcontrib>Erzurumluoglu, A Mesut</creatorcontrib><creatorcontrib>Rodriguez, Santiago</creatorcontrib><title>The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.</description><subject>Chromosomes</subject><subject>Chromosomes, Human, Y - genetics</subject><subject>Genetic Association Studies</subject><subject>Genetic Variation</subject><subject>Genetics, Population</subject><subject>Genome-Wide Association Study</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Molecular Epidemiology</subject><subject>Multifactorial Inheritance - genetics</subject><subject>Observations</subject><subject>Physiological aspects</subject><subject>Quantitative Trait Loci</subject><subject>Recombination, Genetic</subject><subject>Review</subject><subject>Sex Determination Processes</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkc1LAzEQxYMoWtSjVwl48bKaz03jQSiLtkLRSz14Ctk4aVd2NzXZFf3v3VIt-i4zMD_ezPAQOqPkinNNrpfQQqIbMcX30IgRxTMhmNz_0x-h05TeyCBBGCHyEB1xTrkaKzVCj4sV4BdcrGJoQgoN3OAJLkKzruETz4PrE_Yh4umwqKscnrS2_kqQcPA7atY3tsWLaKsunaADb-sEpz_1GD3f3y2KWTZ_mj4Uk3nmBJVdpqjklgOAB0ktU5qwMuc-z60vqfQOgAnrLFDgWjuQNqevAnRZKuI5aM2P0e3Wd92XDbw6aLtoa7OOVWPjlwm2Mv8nbbUyy_BhVK55rulgcPljEMN7D6kzTZUc1LVtIfTJMCEVG9Mx2aAXW3RpazBV68Pg6Da4meRCUqkoEQOVbSkXQ0oR_O4YSswmLPMvrIE___vBjv6Nhn8DXPmP-Q</recordid><startdate>20201029</startdate><enddate>20201029</enddate><creator>Parker, Katherine</creator><creator>Erzurumluoglu, A Mesut</creator><creator>Rodriguez, Santiago</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1322-8138</orcidid><orcidid>https://orcid.org/0000-0001-6551-932X</orcidid></search><sort><creationdate>20201029</creationdate><title>The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits</title><author>Parker, Katherine ; Erzurumluoglu, A Mesut ; Rodriguez, Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chromosomes</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>Genetic Association Studies</topic><topic>Genetic Variation</topic><topic>Genetics, Population</topic><topic>Genome-Wide Association Study</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>Molecular Epidemiology</topic><topic>Multifactorial Inheritance - genetics</topic><topic>Observations</topic><topic>Physiological aspects</topic><topic>Quantitative Trait Loci</topic><topic>Recombination, Genetic</topic><topic>Review</topic><topic>Sex Determination Processes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parker, Katherine</creatorcontrib><creatorcontrib>Erzurumluoglu, A Mesut</creatorcontrib><creatorcontrib>Rodriguez, Santiago</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parker, Katherine</au><au>Erzurumluoglu, A Mesut</au><au>Rodriguez, Santiago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2020-10-29</date><risdate>2020</risdate><volume>11</volume><issue>11</issue><spage>1273</spage><pages>1273-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33137877</pmid><doi>10.3390/genes11111273</doi><orcidid>https://orcid.org/0000-0003-1322-8138</orcidid><orcidid>https://orcid.org/0000-0001-6551-932X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2073-4425
ispartof Genes, 2020-10, Vol.11 (11), p.1273
issn 2073-4425
2073-4425
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7693691
source Publicly Available Content (ProQuest); PubMed Central
subjects Chromosomes
Chromosomes, Human, Y - genetics
Genetic Association Studies
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Haplotypes
Humans
Male
Models, Genetic
Molecular Epidemiology
Multifactorial Inheritance - genetics
Observations
Physiological aspects
Quantitative Trait Loci
Recombination, Genetic
Review
Sex Determination Processes
title The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T16%3A46%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Y%20Chromosome:%20A%20Complex%20Locus%20for%20Genetic%20Analyses%20of%20Complex%20Human%20Traits&rft.jtitle=Genes&rft.au=Parker,%20Katherine&rft.date=2020-10-29&rft.volume=11&rft.issue=11&rft.spage=1273&rft.pages=1273-&rft.issn=2073-4425&rft.eissn=2073-4425&rft_id=info:doi/10.3390/genes11111273&rft_dat=%3Cgale_pubme%3EA645157104%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c415t-7153a3eeefe51a27902b63f66afb15fcee24acae1e399ce5a61d4e9bb70f3e993%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2457281801&rft_id=info:pmid/33137877&rft_galeid=A645157104&rfr_iscdi=true