Itching Caused by TRPV3 (Transient Receptor Potential Vanilloid-3) Activator Application to Skin of Burn Patients

Postburn pruritus is a common complication of scars in burn patients. In our previous study, we discovered increased expression of TRPV3, TRPV4, and TRPA1. Among them, TRPV3, in particular, is predominantly expressed in the epidermis of the tissue of pruritic burn scars. We sought to evaluate the co...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2020-10, Vol.56 (11), p.560
Main Authors: Kim, Hye One, Jin Cheol, Kim, Yu Gyeong, Kong, In Suk, Kwak
Format: Article
Language:English
Subjects:
Cicatrix
Epidermis
Humans
Pruritus - drug therapy
Pruritus - etiology
Skin
TRPV Cation Channels
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Summary:Postburn pruritus is a common complication of scars in burn patients. In our previous study, we discovered increased expression of TRPV3, TRPV4, and TRPA1. Among them, TRPV3, in particular, is predominantly expressed in the epidermis of the tissue of pruritic burn scars. We sought to evaluate the correlation between the expression of TRPV3 activators and itching after application of TRPV3 activator carvacrol over burn scars. Design: This was a double-blind clinical trial with non-randomized distribution. This study was performed in a hospital setting. Patients with itching of burn scars (numerical rating scale (NRS),
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina56110560