Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Background Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf‐lives and can be easily transported, stored, and administered in various settings. Objective To evalu...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2020-11, Vol.34 (6), p.2384-2397
Main Authors: Goggs, Robert, Brainard, Benjamin M., LeVine, Dana N., Calabro, Janine, Harrell, Karyn, Mills, Tracy, Stone, Richard, Davidson, Benjamin, Iacovetta, Christine, Harris, Lauren, Gicking, John, Aslanian, Mary, Ziegler, Ashley, Fulcher, Brenda, Lightfoot, Teresa, Miller, Meredith, Loftus, John, Walton, Rebecca, Blong, April, Kishbaugh, Jennifer, Hale, Anne S.
Format: Article
Language:English
Subjects:
canine
hemorrhage
immune thrombocytopenia
SMALL ANIMAL
transfusion
trehalose
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Summary:Background Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf‐lives and can be easily transported, stored, and administered in various settings. Objective To evaluate the efficacy and safety of a novel trehalose‐stabilized canine lyophilized platelet product in thrombocytopenic dogs with clinically‐evident bleeding. Animals Eighty‐eight dogs with platelet counts
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15922