Clean manufacturing powered by biology: how Amyris has deployed technology and aims to do it better

Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has c...

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Bibliographic Details
Published in:Journal of industrial microbiology & biotechnology 2020-11, Vol.47 (11), p.965-975
Main Authors: Hill, Paul, Benjamin, Kirsten, Bhattacharjee, Binita, Garcia, Fernando, Leng, Joshua, Liu, Chi-Li, Murarka, Abhishek, Pitera, Douglas, Rodriguez Porcel, Elisa Maria, da Silva, Iris, Kraft, Chuck
Format: Article
Language:English
Subjects:
Automation
Biochemistry
Bioinformatics
Biology
Biomedical and Life Sciences
Biotechnology
Cell Culture and Bioengineering - Original Paper
Commercialization
Fermentation
Fermentation, Cell Culture and Bioengineering - Original Paper
Genetic Engineering
Genome editing
Genomes
Inorganic Chemistry
Life Sciences
Microbiology
Synthetic Biology
Technology transfer
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Summary:Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has commercialized nine separate fermentation products over the last decade. This has been accomplished by partnering with the teams at 17 different manufacturing sites around the world. This paper begins with the technology that drives Amyris, describes some key lessons learned from early scale-up experiences, and summarizes the technology transfer procedures and systems that have been built to enable moving more products to market faster. Finally, the breadth of the Amyris product portfolio continues to expand; thus the steps being taken to overcome current challenges (e.g. automated strain engineering can now outpace the rest of the product commercialization timeline) are described.
ISSN:1367-5435
1476-5535
DOI:10.1007/s10295-020-02314-3