Lesion network mapping demonstrates that mind‐wandering is associated with the default mode network

Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind‐wandering. Targeted lesion research has documented impairments in mind‐wandering after damage to the medial prefrontal cortex (mPFC) and hipp...

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Bibliographic Details
Published in:Journal of neuroscience research 2021-01, Vol.99 (1), p.361-373
Main Authors: Philippi, Carissa L., Bruss, Joel, Boes, Aaron D., Albazron, Fatimah M., Deifelt Streese, Carolina, Ciaramelli, Elisa, Rudrauf, David, Tranel, Daniel
Format: Article
Language:English
Subjects:
Aged
Attention - physiology
Brain
Brain - physiology
Brain Injuries - physiopathology
Brain injury
Brain mapping
Brain Mapping - methods
Brain research
Cognition
default mode network
Default Mode Network - physiology
Female
Frontal gyrus
frontoparietal network
Head injuries
Hippocampus
Humans
Injury analysis
lesion network mapping
Lesions
Male
Mapping
Medical imaging
Middle Aged
mind‐wandering
Neural networks
Neuroimaging
Prefrontal cortex
self‐generated cognition
spontaneous thought
Traumatic brain injury
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Summary:Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind‐wandering. Targeted lesion research has documented impairments in mind‐wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However, no lesion studies to date have applied lesion network mapping to identify common networks associated with deficits in mind‐wandering. In lesion network mapping, resting‐state functional connectivity data from healthy participants are used to infer which brain regions are functionally connected to each lesion location from a sample with brain injury. In the current study, we conducted a lesion network mapping analysis to test the hypothesis that lesions affecting the DMN and FPN would be associated with diminished mind‐wandering. We assessed mind‐wandering frequency on the Imaginal Processes Inventory (IPI) in participants with brain injury (n = 29) and healthy comparison participants without brain injury (n = 19). Lesion network mapping analyses showed the strongest association of reduced mind‐wandering with the left inferior parietal lobule within the DMN. In addition, traditional lesion symptom mapping results revealed that reduced mind‐wandering was associated with lesions of the dorsal, ventral, and anterior sectors of mPFC, parietal lobule, and inferior frontal gyrus in the DMN (p 
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.24648