Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice

During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that...

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Bibliographic Details
Published in:Scientific reports 2020-11, Vol.10 (1), p.20866-20866, Article 20866
Main Authors: Pennington, Kathleen A., Dong, Yuanlin, Ruano, Simone Hernandez, van der Walt, Nicola, Sangi-Haghpeykar, Haleh, Yallampalli, Chandrasekhar
Format: Article
Language:English
Subjects:
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692/699
Adaptation
Adipose tissue
Adrenomedullin
Adrenomedullin - metabolism
Animal models
Animals
Diabetes mellitus
Diabetes, Gestational - metabolism
Diet, High-Fat
Energy expenditure
Energy metabolism
Energy Metabolism - physiology
Fat metabolism
Female
Fetal Development - physiology
Fetuses
Gene expression
High fat diet
Homeostasis
Humanities and Social Sciences
Intra-Abdominal Fat - metabolism
Lipid metabolism
Lipid Metabolism - physiology
Lipolysis
Lipolysis - physiology
Metabolism
Mice
Mice, Inbred C57BL
multidisciplinary
Obesity - metabolism
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Receptor activity modifying proteins
Science
Science (multidisciplinary)
Sucrose
Sugars - metabolism
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Summary:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipid metabolism are mediated by adrenomedullin (ADM) in normal and GDM pregnancies. Our objectives were: (1) evaluate energy and fat homeostasis in our GDM mouse model and (2) determine if ADM may play a role in these changes. Female mice were placed on either control (P-CD) or high fat, high sucrose diet (P-HFHS) 1 week prior to and throughout pregnancy. Mice were placed into comprehensive lab animal monitoring system (CLAMS) chambers throughout pregnancy. Visceral adipose tissue (VAT) was collected at d17.5 of pregnancy for analysis. Energy Expenditure was significantly increased (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-77529-6