The role of intra-abdominal pressure in human testicular migration

• Published in: International Brazilian Journal of Urology 2021-01, Vol.47 (1), p.36-44
• Main Authors: Logsdon, Natasha T., Sampaio, Francisco J.B., Favorito, Luciano Alves
• Format: Article
• Language: English
• Subjects: Cryptorchidism; Intra-Abdominal pressure; Prune Belly Syndrome; Review
• ISSN: 1677-5538; 1677-6119
• DOI: 10.1590/s1677-5538.ibju.2021.99.03

ABSTRACT Objectives: This review aims to study the role of the abdominal wall in testicular migration process during the human fetal period. Materials and Methods: We performed a descriptive review of the literature about the role of the abdominal wall in testicular migration during the human fetal period. Results: The rise in intra-abdominal pressure is a supporting factor for testicular migration. This process has two phases: the abdominal and the inguinal-scrotal stages. The passage of the testis through the inguinal canal occurs very quickly between 21 and 25 WPC. Bilateral cryptorchidism in Prune Belly syndrome is explained by the impaired contraction of the muscles of the abdominal wall; mechanical obstruction due to bladder distention and structural alteration of the inguinal canal, which hampers the passage of the testis during the inguinoscrotal stage of testicular migration. Abdominal wall defects as gastroschisis and omphaloceles are associated with undescended testes in around 30 to 40% of the cases. Conclusions: Abdominal pressure wound is an auxiliary force in testicular migration. Patients with abdominal wall defects are associated with undescendend testis in more than 30% of the cases probably due to mechanical factors; the Prune Belly Syndrome has anatomical changes in the anterior abdominal wall that hinder the increase of intra-abdominal pressure which could be the cause of cryptorchidism in this syndrome.