Reprogramming of gastrointestinal cancer cells

Cell reprogramming reverts cells to multipotent, preprogrammed states by re‐establishing epigenetic markers. It can also induce considerable malignant phenotype modification. Because key events in cancer relapse and metastasis, including epithelial–mesenchymal transition phenotypes, are regulated pr...

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Bibliographic Details
Published in:Cancer science 2012-03, Vol.103 (3), p.393-399
Main Authors: Dewi, DyahLaksmi, Ishii, Hideshi, Haraguchi, Naotsugu, Nishikawa, Shimpei, Kano, Yoshihiro, Fukusumi, Takahito, Ohta, Katsuya, Miyazaki, Susumu, Ozaki, Miyuki, Sakai, Daisuke, Satoh, Taroh, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell Differentiation - genetics
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
Epigenesis, Genetic - genetics
epigenetics
Epithelial-Mesenchymal Transition - genetics
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Hibernation
Humans
Induced Pluripotent Stem Cells - pathology
Metastases
miRNA
Neoplastic Stem Cells - pathology
Review
Stem cells
Transcription factors
Tumor cells
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Summary:Cell reprogramming reverts cells to multipotent, preprogrammed states by re‐establishing epigenetic markers. It can also induce considerable malignant phenotype modification. Because key events in cancer relapse and metastasis, including epithelial–mesenchymal transition phenotypes, are regulated primarily by reversible and transient epigenetic modifications rather than the accumulation of irreversible and stable genetic abnormalities, studying dynamic mechanisms regulating these biological processes is important. Transcription factors for induced pluripotent stem cells and non‐coding microRNAs allow pluripotent phenotype induction. We present the current knowledge of the possible applications of cell reprogramming in reducing aggressive phenotype expression, which can induce tumor cell hibernation and maintain appropriate phenotypes, thereby minimizing relapse and metastasis after surgical resection of gastrointestinal cancer. (Cancer Sci 2012; 103: 393–399)
ISSN:1347-9032
1349-7006
DOI:10.1111/j.1349-7006.2011.02184.x