TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) exhibits high recurrence and metastasis rates. Although targeted therapy has significantly improved the prognosis of some patients with ccRCC, the median survival rate remains poor. In this article, we used a series of bioinformatics analyses to identify TYROB...

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Bibliographic Details
Published in:FEBS open bio 2020-12, Vol.10 (12), p.2588-2604
Main Authors: Wu, Ping, Xiang, Tingting, Wang, Jing, Lv, Run, Wu, Guangzhen
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Bioinformatics
bioinformatics analysis
biomarker
Biomarkers
clear cell renal cell carcinoma
Clear cell-type renal cell carcinoma
Correlation analysis
Diagnosis
Gene expression
Genomes
HRG
Immune checkpoint
Immunology
Immunotherapy
Kidney cancer
Ligands
Medical prognosis
Metastases
Metastasis
Molecular modelling
Ontology
Prognosis
Proteins
Software
Survival analysis
TYROBP
Web sites
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Summary:Clear cell renal cell carcinoma (ccRCC) exhibits high recurrence and metastasis rates. Although targeted therapy has significantly improved the prognosis of some patients with ccRCC, the median survival rate remains poor. In this article, we used a series of bioinformatics analyses to identify TYROBP as a potential target for diagnosis and treatment of ccRCC. Clear cell renal cell carcinoma (ccRCC) exhibits high recurrence and metastasis rates. Although target therapy has significantly improved the prognosis of some patients with ccRCC, the median survival rate remains poor. Thus, there remains a need for the identification of novel potential targets for diagnosis and therapy. Here, we screened differentially expressed genes between ccRCC and normal tissues through analyzing The Cancer Genome Atlas database. We identified 55 up‐regulated and 67 down‐regulated genes associated with poor prognosis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that these genes were associated with glycometabolic process, complement and coagulation cascades. In addition, the eight down‐regulated genes (HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG, and HMGCS2) and two up‐regulated genes (SERPINE1 and TYROBP) were filtered out. Finally, TYROBP was selected through repeated verification of various databases. High expression of TYROBP is associated with low survival rate in ccRCC, is closely related to immune cell infiltration and is coexpressed with Programmed cell death protein‐1(PD‐1) and Cytotoxic T lymphocyte‐associated antigen‐4(CTLA‐4). In conclusion, TYROBP may have potential for diagnosis and treatment of ccRCC.
ISSN:2211-5463
2211-5463
DOI:10.1002/2211-5463.12993