Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients

Depression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included...

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Bibliographic Details
Published in:Molecular psychiatry 2020-12, Vol.25 (12), p.3186-3197
Main Authors: Wang, Xuan, Wang, Neng, Zhong, Lidan, Wang, Shengqi, Zheng, Yifeng, Yang, Bowen, Zhang, Juping, Lin, Yi, Wang, Zhiyu
Format: Article
Language:English
Subjects:
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692/699/476/1414
Anxiety
Behavioral Sciences
Biological Psychology
Breast cancer
Breast Neoplasms
Cancer
Depression
Depression, Mental
Female
Humans
Mastectomy
Medical prognosis
Medicine
Medicine & Public Health
Mental depression
Mental disorders
Meta-analysis
Middle Aged
Mortality
Neoplasm Recurrence, Local
Neurosciences
Patient outcomes
Pharmacotherapy
Prognosis
Psychiatry
Psychological aspects
Relapse
Review
Review Article
Systematic review
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Summary:Depression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included. The results showed that depression was associated with cancer recurrence [1.24 (1.07, 1.43)], all-cause mortality [1.30 (1.23, 1.36)], and cancer-specific mortality [1.29 (1.11, 1.49)]. However, anxiety was associated with recurrence [1.17 (1.02, 1.34)] and all-cause mortality [1.13 (1.07, 1.19)] but not with cancer-specific mortality [1.05 (0.82, 1.35)]. Comorbidity of depression and anxiety is associated with all-cause mortality [1.34 (1.24, 1.45)] and cancer-specific mortality [1.45 (1.11, 1.90)]. Subgroup analyses demonstrated that clinically diagnosed depression and anxiety, being female and of younger age (
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-020-00865-6