Progressive multifocal leukoencephalopathy in an HIV patient was diagnosed by 3 times lumbar punctures and 2 times brain biopsies

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by JC virus (JCV) and is difficult to diagnose. We report on a male HIV-positive patient with PML finally diagnosed by 3 times lumbar punctures and 2 times brain biopsies. Negative r...

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Bibliographic Details
Published in:Journal of neurovirology 2020-12, Vol.26 (6), p.952-956
Main Authors: Wang, Mengyan, Zhang, Zhongdong, Shi, Jinchuan, Liu, Hong, Zhang, Binhai, Yan, Jun
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Case Report
Immunology
Infectious Diseases
Neurology
Neurosciences
Virology
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Summary:Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by JC virus (JCV) and is difficult to diagnose. We report on a male HIV-positive patient with PML finally diagnosed by 3 times lumbar punctures and 2 times brain biopsies. Negative results of JCV-PCR in cerebrospinal fluid (CSF) do not rule out the diagnosis of PML when clinical manifestations and neuroimaging features suspected PML. It is necessary to obtain new CSF and make repeat tests and even perform brain biopsy.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-020-00893-6