Identifying blood pressure loci whose effects are modulated by multiple lifestyle exposures

Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene–multiple lifestyle exposure interactions to find novel BP loci. For each of 6...

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Bibliographic Details
Published in:Genetic epidemiology 2020-09, Vol.44 (6), p.629-641
Main Authors: Osazuwa‐Peters, Oyomoare L., Waken, R. J., Schwander, Karen L., Sung, Yun Ju, Vries, Paul S., Hartz, Sarah M., Chasman, Daniel I., Morrison, Alanna C., Bierut, Laura J., Xiong, Chengjie, Fuentes, Lisa, Rao, D. C.
Format: Article
Language:English
Subjects:
Adult
Alcoholism - genetics
Blood pressure
Blood Pressure - genetics
Educational Status
Exercise
Female
Genetic Loci
gene–environment interaction
Genome-Wide Association Study
Genomes
Humans
Life Style
lifestyle risk score
Lifestyles
loci discovery
Longitudinal Studies
Male
Middle Aged
multiple lifestyle exposures
Physical activity
Polymorphism, Single Nucleotide - genetics
Risk Factors
Smoking
Smoking - genetics
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Summary:Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene–multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity) on BP. Using the LRS, we performed genome‐wide gene–environment interaction analysis in systolic and diastolic BP using the joint 2 degree of freedom (DF) and 1 DF interaction tests. We identified one genome‐wide significant (p 
ISSN:0741-0395
1098-2272
1098-2272
DOI:10.1002/gepi.22292