Performance Characteristics of Pulmonary Function Tests for the Detection of Interstitial Lung Disease in Adults With Early Diffuse Cutaneous Systemic Sclerosis

Objective Interstitial lung disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc). Although pulmonary function tests (PFTs) are commonly used to screen for ILD in patients with SSc, studies have shown that they lack sensitivity for the detection of ILD in general SSc...

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Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2020-11, Vol.72 (11), p.1892-1896
Main Authors: Bernstein, Elana J., Jaafar, Sara, Assassi, Shervin, Domsic, Robyn T., Frech, Tracy M., Gordon, Jessica K., Broderick, Rachel J., Hant, Faye N., Hinchcliff, Monique E., Shah, Ami A., Shanmugam, Victoria K., Steen, Virginia D., Khanna, Dinesh
Format: Article
Language:English
Subjects:
Adult
Aged
Algorithms
Carbon monoxide
Computed tomography
Female
Humans
Lung - physiopathology
Lung diseases
Lung Diseases, Interstitial - diagnosis
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - physiopathology
Male
Middle Aged
Pulmonary functions
Registries
Respiratory function
Respiratory Function Tests
Retrospective Studies
Scleroderma
Scleroderma, Diffuse - complications
Scleroderma, Diffuse - physiopathology
Sensitivity
Sensitivity and Specificity
Systemic sclerosis
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Summary:Objective Interstitial lung disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc). Although pulmonary function tests (PFTs) are commonly used to screen for ILD in patients with SSc, studies have shown that they lack sensitivity for the detection of ILD in general SSc cohorts. This study was undertaken to assess the performance characteristics of PFTs for the detection of ILD in patients with early diffuse cutaneous SSc (dcSSc), a population at high risk for the development of ILD. Methods We performed a retrospective cohort study of patients enrolled in the Prospective Registry of Early Systemic Sclerosis at 11 sites in the US between April 2012 and January 2019. Patients were included if they underwent spirometry and high‐resolution computed tomography (HRCT) of the chest. We calculated the performance characteristics of PFTs for the detection of ILD on HRCT. Results The study included 212 patients, 54% of whom had radiographic ILD. For the detection of ILD on HRCT imaging, a forced vital capacity (FVC)
ISSN:2326-5191
2326-5205
DOI:10.1002/art.41415