Prognostic value of brain natriuretic peptide vs history of heart failure hospitalization in a large real‐world population

• Published in: Clinical cardiology (Mahwah, N.J.) N.J.), 2020-12, Vol.43 (12), p.1501-1510
• Main Authors: Zile, Michael R., Desai, Akshay S., Agarwal, Rahul, Bharmi, Rupinder, Dalal, Nirav, Adamson, Philip B., Maisel, Alan S.
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Biomarkers - blood; B‐type natriuretic peptide; Clinical Investigations; Codes; Ejection fraction; Electronic health records; Female; Follow-Up Studies; Gender; Health care; Heart failure; Heart Failure - blood; Heart Failure - mortality; Hospitalization; Hospitalization - statistics & numerical data; Hospitals; Humans; Insurance claims; Laboratories; Male; Medical records; Middle Aged; Morbidity; Mortality; Names; Natriuretic Peptide, Brain - blood; Nursing homes; Patients; Peptide Fragments - blood; Peptides; Population; Prognosis; Protein Precursors; Retrospective Studies; Risk Factors; Survival Rate - trends; United States - epidemiology
• ISSN: 0160-9289; 1932-8737; 1932-8737
• DOI: 10.1002/clc.23468

Background In heart failure (HF) patients, both natriuretic peptides (NP) and previous HF hospitalization (pHFH) have been used to predict prognosis. Hypothesis In a large real‐world population, both NP levels and pHFH have independent and interdependent predictive value for clinical outcomes of HFH and all‐cause mortality. Methods Linked electronic health records and insurance claims data from Decision Resource Group were used to identify HF patients that had a BNP or NT‐proBNP result between January 2012 and December 2016. NT‐proBNP was converted into BNP equivalents by dividing by 4. Index event was defined as most recent NP on or after 1 January 2012. Patients with incomplete records or age