Normative Analysis of Individual Brain Differences Based on a Population MRI-Based Atlas of Cynomolgus Macaques

Abstract The developmental trajectory of the primate brain varies substantially with aging across subjects. However, this ubiquitous variability between individuals in brain structure is difficult to quantify and has thus essentially been ignored. Based on a large-scale structural magnetic resonance...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2021-01, Vol.31 (1), p.341-355
Main Authors: Lv, Qiming, Yan, Mingchao, Shen, Xiangyu, Wu, Jing, Yu, Wenwen, Yan, Shengyao, Yang, Feng, Zeljic, Kristina, Shi, Yuequan, Zhou, Zuofu, Lv, Longbao, Hu, Xintian, Menon, Ravi, Wang, Zheng
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Brain - pathology
Brain Mapping
Head - pathology
Image Processing, Computer-Assisted - methods
Individuality
Macaca
Magnetic Resonance Imaging - methods
Organ Size - physiology
Original
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Summary:Abstract The developmental trajectory of the primate brain varies substantially with aging across subjects. However, this ubiquitous variability between individuals in brain structure is difficult to quantify and has thus essentially been ignored. Based on a large-scale structural magnetic resonance imaging dataset acquired from 162 cynomolgus macaques, we create a species-specific 3D template atlas of the macaque brain, and deploy normative modeling to characterize individual variations of cortical thickness (CT) and regional gray matter volume (GMV). We observed an overall decrease in total GMV and mean CT, and an increase in white matter volume from juvenile to early adult. Specifically, CT and regional GMV were greater in prefrontal and temporal cortices relative to early unimodal areas. Age-dependent trajectories of thickness and volume for each cortical region revealed an increase in the medial temporal lobe, and decreases in all other regions. A low percentage of highly individualized deviations of CT and GMV were identified (0.0021%, 0.0043%, respectively, P 
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhaa229