Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role

• Published in: International journal of molecular sciences 2020-11, Vol.21 (23), p.9100
• Main Authors: Jeremic, Jovana N, Jakovljevic, Vladimir Lj, Zivkovic, Vladimir I, Srejovic, Ivan M, Bradic, Jovana V, Milosavljevic, Isidora M, Mitrovic, Slobodanka Lj, Jovicic, Nemanja U, Bolevich, Sergey B, Svistunov, Andrey A, Tyagi, Suresh C, Jeremic, Nevena S
• Format: Article
• Language: English
• Subjects: Allyl Compounds - pharmacology; Allyl Compounds - therapeutic use; Animals; Apoptosis; Bcl-2 protein; Blood Glucose - metabolism; Blood pressure; Cardiotonic Agents - pharmacology; Cardiotonic Agents - therapeutic use; Communication; Diallyl trisulfide; Edema; Fasting; Garlic; Garlic - chemistry; Gene expression; Gene Expression Regulation - drug effects; Glucose; Glucose Tolerance Test; Heart attacks; Heart Function Tests - drug effects; Heart rate; Homocysteine; Hydrogen sulfide; Insulin - blood; Insulin resistance; Ischemia; Lipids; Lymph Nodes - drug effects; Lymph Nodes - pathology; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - drug therapy; Metabolic Syndrome - physiopathology; Myocardium - pathology; NF-κB protein; Oxidation-Reduction; Oxidative Stress - drug effects; Polysulfides; Protein expression; Proteins; Rats, Wistar; Reperfusion; Sulfides - pharmacology; Sulfides - therapeutic use; Sulfur
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21239100

This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpose, we used 36 male rats divided into control rats, rats with MetS and MetS rats treated with 40 mg/kg of DATS every second day for 3 weeks. In the first part, we studied the impact of DATS on MetS control and found that DATS significantly raised H S, decreased homocysteine and glucose levels and enhanced lipid and antioxidative, while reducing prooxidative parameters. Additionally, this polysulfide improved cardiac function. In the second part, we investigated the impact of DATS on ex vivo induced ischemia/reperfusion (I/R) heart injury and found that DATS consumption significantly improved cardiodynamic parameters and prevented oxidative and histo-architectural variation in the heart. In addition, DATS significantly increased relative gene expression of eNOS, SOD-1 and -2, Bcl-2 and decreased relative gene expression of NF-κB, IL-17A, Bax, and caspases-3 and -9. Taken together, the data show that DATS can effectively mitigate MetS and have protective effects against ex vivo induced myocardial I/R injury in MetS rat.