Nano targeted Therapies Made of Lipids and Polymers have Promising Strategy for the Treatment of Lung Cancer

The introduction of nanoparticles made of polymers, protein, and lipids as drug delivery systems has led to significant progress in modern medicine. Since the application of nanoparticles in medicine involves the use of biodegradable, nanosized materials to deliver a certain amount of chemotherapeut...

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Bibliographic Details
Published in:Materials 2020-11, Vol.13 (23), p.5397
Main Authors: Essa, Marwa Labib, El-Kemary, Maged Abdeltawab, Ebrahem Saied, Eman Mohammed, Leporatti, Stefano, Nemany Hanafy, Nemany Abdelhamid
Format: Article
Language:English
Subjects:
Biodegradability
Cancer therapies
Chemotherapy
Clinical trials
Drug delivery systems
Drugs
Encapsulation
Lipids
Liposomes
Lung cancer
Medical prognosis
Medicine
Nanoparticles
Nanotechnology
Permeability
Polymers
Radiation therapy
Review
Strategy
Toxicity
Tumors
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Summary:The introduction of nanoparticles made of polymers, protein, and lipids as drug delivery systems has led to significant progress in modern medicine. Since the application of nanoparticles in medicine involves the use of biodegradable, nanosized materials to deliver a certain amount of chemotherapeutic agents into a tumor site, this leads to the accumulation of these nanoencapsulated agents in the right region. This strategy minimizes the stress and toxicity generated by chemotherapeutic agents on healthy cells. Therefore, encapsulating chemotherapeutic agents have less cytotoxicity than non-encapsulation ones. The purpose of this review is to address how nanoparticles made of polymers and lipids can successfully be delivered into lung cancer tumors. Lung cancer types and their anatomies are first introduced to provide an overview of the general lung cancer structure. Then, the rationale and strategy applied for the use of nanoparticle biotechnology in cancer therapies are discussed, focusing on pulmonary drug delivery systems made from liposomes, lipid nanoparticles, and polymeric nanoparticles. Many nanoparticles fabricated in the shape of liposomes, lipid nanoparticles, and polymeric nanoparticles are summarized in our review, with a focus on the encapsulated chemotherapeutic molecules, ligand-receptor attachments, and their targets. Afterwards, we highlight the nanoparticles that have demonstrated promising results and have been delivered into clinical trials. Recent clinical trials that were done for successful nanoparticles are summarized in our review.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma13235397