AlphaB-crystallin and breast cancer: role and possible therapeutic strategies

AlphaB-crystallin (HSPB5) is one of the most prominent and well-studied members of the small heat shock protein (sHsp) family. To date, it is known that this protein modulates significant cellular processes and therefore, it is not surprising that its deregulation is involved in various human pathol...

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Bibliographic Details
Published in:Cell stress & chaperones 2021-01, Vol.26 (1), p.19-28
Main Authors: Caporossi, Daniela, Parisi, Attilio, Fantini, Cristina, Grazioli, Elisa, Cerulli, Claudia, Dimauro, Ivan
Format: Article
Language:English
Subjects:
alpha-Crystallin B Chain - analysis
alpha-Crystallin B Chain - antagonists & inhibitors
alpha-Crystallin B Chain - metabolism
Animals
Antineoplastic Agents - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer Research
Cell Biology
Drug Discovery
Female
Humans
Immunology
MINI REVIEW
Molecular Targeted Therapy
Neurosciences
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Summary:AlphaB-crystallin (HSPB5) is one of the most prominent and well-studied members of the small heat shock protein (sHsp) family. To date, it is known that this protein modulates significant cellular processes and therefore, it is not surprising that its deregulation is involved in various human pathologies, including cancer diseases. Despite the pathogenic significance of HSPB5 in cancer and its regulatory mechanism related to aggressiveness is poorly understood, several reports describe the association of breast carcinoma progression with HSPB5, whose expression is also considered an independent predictor of breast cancer metastasis to the brain. Indeed, numerous authors indicate HSPB5 as a new valuable biomarker for clinicopathological parameters and poor prognosis in breast cancer. Considering the cytoprotective, anti-apoptotic, pro-angiogenic, and pro-metastatic properties of the sHsps, it is not surprising that they are considered as promising targets for anticancer treatment, even though, at present, a deeper understanding of their mode of action is needed to allow the development of precise therapeutic interventions. Data on the direct inhibition of different sHsps demonstrate promising results in cancer pathologies; however, specific strategies against HSPB5 have not been considered. This review highlights the most relevant findings on HSPB5 and its role in breast cancer, as well as the possible strategies in using HSPB5 inhibition for therapeutic purposes.
ISSN:1355-8145
1466-1268
DOI:10.1007/s12192-020-01175-0