Acrokeratosis paraneoplastica (Bazex syndrome) as the presenting sign of pancreatic adenocarcinoma

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic skin condition characterised by acral psoriasiform plaques, with a predilection for the nose, ears, hands and feet. It typically presents before the discovery of an internal malignancy and is often misdiagnosed as an inflammator...

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Bibliographic Details
Published in:BMJ case reports 2020-12, Vol.13 (12), p.e236514
Main Authors: Horton, Luke, Bedford, Lisa M, Daveluy, Steven
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - ethnology
African Americans
Aged
Biopsy
Black or African American
Cancer
cancer intervention
Carcinoma, Basal Cell - ethnology
Carcinoma, Basal Cell - etiology
Case Report
Case reports
Colon
Dermatitis
dermatology
Diagnosis, Differential
Disease
Erythema
Fingers & toes
Genealogy
Growth factors
Humans
Hypotrichosis - ethnology
Hypotrichosis - etiology
Lung cancer
Lymphatic system
Male
Medical imaging
pancreas and biliary tract
Pancreatic cancer
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - ethnology
Patients
screening (oncology)
Skin
Skin cancer
Skin Neoplasms - ethnology
Skin Neoplasms - etiology
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Description
Summary:Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic skin condition characterised by acral psoriasiform plaques, with a predilection for the nose, ears, hands and feet. It typically presents before the discovery of an internal malignancy and is often misdiagnosed as an inflammatory dermatitis that does not respond to treatment. It is associated with squamous cell carcinoma of the aerodigestive tract and lung, as well as adenocarcinoma of the lung, colon and gastrum. Here, we describe the second reported case of Bazex syndrome in the setting of pancreatic adenocarcinoma and the first such case in a patient of African ancestry.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2020-236514