SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis

Background. The increased risk and poor survival outcome of cervical adenocarcinoma (CAC) demand for effective early diagnostic biomarkers that can predict the disease progression and outcome. The purpose of this study was to investigate the value of methylation status of SOX1 and PAX1 in the detect...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-8
Main Authors: Wu, Na-Yi Yuan, Cai, Jingting, Zhao, Xueheng, Zhang, Xiaoye, Zhao, Zitong, Wang, Jing
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - metabolism
Age
Aged
Algorithms
Biomarkers
Biomarkers, Tumor - metabolism
Cervical cancer
Cervical Intraepithelial Neoplasia - metabolism
Deoxyribonucleic acid
Development and progression
Diagnostic systems
Disease Progression
DNA
DNA Methylation
Epigenetics
Female
Genes
Humans
Kaplan-Meier Estimate
Lymphatic system
Mathematical models
Medical prognosis
Metastasis
Methods
Methylation
Middle Aged
Models, Theoretical
Ovarian cancer
Paired Box Transcription Factors - metabolism
Paraffin
Paraffins
Physiological aspects
Polymerase Chain Reaction
Prognosis
Progression-Free Survival
Regression analysis
Regression models
Risk
Risk groups
SOXB1 Transcription Factors - metabolism
Survival
Tissues
Transcription factors
Treatment Outcome
Uterine Cervical Neoplasms - metabolism
Vaginal Smears
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. The increased risk and poor survival outcome of cervical adenocarcinoma (CAC) demand for effective early diagnostic biomarkers that can predict the disease progression and outcome. The purpose of this study was to investigate the value of methylation status of SOX1 and PAX1 in the detection and prognosis of CAC. Methods. We performed a quantitative methylation-specific polymerase chain reaction in 205 cervical paraffin-embedded specimens (175 CACs, 30 noncancer cervical tissues). Overall and progression-free survival (OS and PFS, respectively) rates were calculated and compared using the Kaplan-Meier method. The prognostic value of SOX1m and PAX1m on CAC patients was assessed by the Cox regression model. A mathematical formula combining SOX1m, PAX1m, and age was constructed for survival prediction. Results. The methylation status of SOX1 and PAX1 was higher in CAC tissues than in noncancer cervical tissues. In addition, SOX1m-positive CAC patients showed a higher 5-year OS rate than SOX1m-negative patients. In CAC patients with smaller tumor size (
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/3981529