Nanotechnology in pulmonary medicine

Nanotechnology in medicine—nanomedicine—is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multidrug r...

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Bibliographic Details
Published in:Current opinion in pharmacology 2021-02, Vol.56, p.85-92
Main Authors: Doroudian, Mohammad, O’ Neill, Andrew, Mac Loughlin, Ronan, Prina-Mello, Adriele, Volkov, Yuri, Donnelly, Seamas C.
Format: Article
Language:English
Subjects:
Animals
Asthma
Coronavirus Infections - drug therapy
COVID- 19
Cystic fibrosis
Drug Carriers
Drug Resistance - physiology
Humans
Lung cancer
Nano carrier
Nanomedicine
Nanotechnology - methods
Pneumonia
Pulmonary Medicine - methods
Respiratory disease
Respiratory Tract Diseases - drug therapy
Tuberculosis
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Summary:Nanotechnology in medicine—nanomedicine—is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multidrug resistance, adverse side effects of conventional therapeutic agents, novel imaging, and earlier disease detection. Nanomedicine is also being applied to tackle the new emerging infectious diseases, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), influenza A virus subtype H1N1 (A/H1N1), and more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review we provide both a historical overview of the application of nanomedicine to respiratory diseases and more recent cutting-edge approaches such as nanoparticle-mediated combination therapies, novel double-targeted nondrug delivery system for targeting, stimuli-responsive nanoparticles, and theranostic imaging in the diagnosis and treatment of pulmonary diseases.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2020.11.002