Tyrosol May Prevent Obesity by Inhibiting Adipogenesis in 3T3-L1 Preadipocytes

Tyrosol (TR), a major polyphenol found in extra virgin olive oil (EVOO), exerts several antioxidant effects. However, only scarce evidences are present regarding its activity on adipocytes and obesity. This study evaluated the role of TR in adipogenesis. Murine 3T3-L1 preadipocytes were incubated wi...

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Published in:Oxidative medicine and cellular longevity 2020, Vol.2020, p.4794780-12
Main Authors: Pacifici, Francesca, Farias, Carolina Lane Alves, Rea, Silvia, Capuani, Barbara, Feraco, Alessandra, Coppola, Andrea, Mammi, Caterina, Pastore, Donatella, Abete, Pasquale, Rovella, Valentina, Salimei, Chiara, Lombardo, Mauro, Caprio, Massimiliano, Bellia, Alfonso, Sbraccia, Paolo, Di Daniele, Nicola, Lauro, Davide, Della-Morte, David
Format: Article
Language:English
Subjects:
Adipocytes
Cell cycle
Cell growth
Diet
Gene expression
Glucose
Laboratories
Lipids
Obesity
Oxidative stress
Polyphenols
Triglycerides
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Summary:Tyrosol (TR), a major polyphenol found in extra virgin olive oil (EVOO), exerts several antioxidant effects. However, only scarce evidences are present regarding its activity on adipocytes and obesity. This study evaluated the role of TR in adipogenesis. Murine 3T3-L1 preadipocytes were incubated with TR (300 and 500 μM), and TR administration inhibited adipogenesis by downregulation of several adipogenic factors (leptin and aP2) and transcription factors (C/EBPα, PPARγ, SREBP1c, and Glut4) and by modulation of the histone deacetylase sirtuin 1. After complete differentiation, adipocytes treated with 300 and 500 μM TR showed a reduction of 20% and 30% in lipid droplets, respectively. Intracellular triglycerides were significantly reduced after TR treatment (p
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/4794780