Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: A 13N-ammonia PET study

It is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and sy...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2020-12, Vol.27 (6), p.2234-2242
Main Authors: Juarez-Orozco, Luis Eduardo, Monroy-Gonzalez, Andrea G., van der Zant, Friso M., Hoogvorst, Nick, Slart, Riemer H.J.A., Knol, Remco J.J.
Format: Article
Language:English
Subjects:
Cardiology
Heart failure
Imaging
mechanical synchrony
Medicine
Medicine & Public Health
myocardial perfusion
Nuclear Medicine
Original
Original Article
Positron emission tomography
Radiology
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Summary:It is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic HF. We studied 98 patients with chronic HF who underwent rest and stress Nitrogen-13 ammonia PET. Multivariate analyses of covariance were performed to determine relevant predictors of synchrony (measured as bandwidth, standard deviation, and entropy). In our population, there were 43 (44%) women and 55 men with a mean age of 71 ± 9.6 years. The SRS was the strongest independent predictor of mechanical synchrony variables (p < .01), among other considered predictors including: age, sex, body mass index, smoking, diabetes mellitus, dyslipidemia, hypertension, rest myocardial blood flow (MBF), and myocardial perfusion reserve (MPR). Results were similar when considering stress MBF instead of MPR. The existence and extent of fixed perfusion defects, but not the quantitative PET myocardial perfusion parameters (sMBF and MPR), constitute a significant independent predictor of ventricular mechanical synchrony in patients with chronic HF.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-018-01507-9