Antiaging Therapies, Cognitive Impairment, and Dementia

Abstract Aging is a powerful risk factor for the development of many chronic diseases including dementia. Research based on disease models of dementia have yet to yield effective treatments, therefore it is opportune to consider whether the aging process itself might be a potential therapeutic targe...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-09, Vol.75 (9), p.1643-1652
Main Authors: Wahl, Devin, Anderson, Rozalyn M, Le Couteur, David G
Format: Article
Language:English
Subjects:
Aging
Aging - drug effects
Aging - physiology
Animals
Cognitive ability
Cognitive Dysfunction - prevention & control
Dementia
Dementia - prevention & control
Dementia disorders
Humans
Life span
Medical treatment
Risk factors
THE JOURNAL OF GERONTOLOGY: Biological Sciences
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Summary:Abstract Aging is a powerful risk factor for the development of many chronic diseases including dementia. Research based on disease models of dementia have yet to yield effective treatments, therefore it is opportune to consider whether the aging process itself might be a potential therapeutic target for the treatment and prevention of dementia. Numerous cellular and molecular pathways have been implicated in the aging process and compounds that target these processes are being developed to slow aging and delay the onset of age-associated conditions. A few particularly promising therapeutic agents have been shown to influence many of the main hallmarks of aging and increase life span in rodents. Here we discuss the evidence that some of these antiaging compounds may beneficially affect brain aging and thereby lower the risk for dementia.
ISSN:1079-5006
1758-535X
1758-535X
DOI:10.1093/gerona/glz135