Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model

Traumatic brain injury (TBI) is among the most debilitating neurological disorders with inadequate therapeutic options. It affects all age groups globally leading to post-TBI behavioral challenges and life-long disabilities requiring interventions for these health issues. In the current study, C57BL...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-12
Main Authors: Alanazi, Ahmed Z., Alshammari, Musaad A., Alasmari, Fawaz, Alanazi, Mohammed Mufadhe, Alamri, Faisal F., Sivandzade, Farzane, Shakeel, Waleed, Rasool, Muhammad Fawad, Javaid, Sana, Imran, Imran, Mohany, Mohamed, Assiri, Mohammed A., Alqahtani, Faleh, Al-Rejaie, Salim S.
Format: Article
Language:English
Subjects:
Animal cognition
Antioxidants
Behavioral assessment
Brain
Complications and side effects
Cytokines
Disabilities
Dosage and administration
Drug development
Drug therapy, Combination
Drugs
Exploratory behavior
Field tests
Gene expression
Head injuries
Inflammation
Injuries
Injury prevention
Ketamine
Metabolites
Metabolomics
Methods
Modulators
Neurological diseases
Neuromodulation
Neuroprotection
NF-κB protein
Nitric-oxide synthase
Object recognition
Open-field behavior
Pathophysiology
Pattern recognition
Perampanel
Spontaneous alternation
Trauma
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) is among the most debilitating neurological disorders with inadequate therapeutic options. It affects all age groups globally leading to post-TBI behavioral challenges and life-long disabilities requiring interventions for these health issues. In the current study, C57BL/6J mice were induced with TBI through the weight-drop method, and outcomes of acutely administered ketamine alone and in combination with perampanel were observed. The impact of test drugs was evaluated for post-TBI behavioral changes by employing the open field test (OFT), Y-maze test, and novel object recognition test (NOR). After that, isolated plasma and brain homogenates were analyzed for inflammatory modulators, i.e., NF-κB and iNOS, through ELISA. Moreover, metabolomic studies were carried out to further authenticate the TBI rescuing potential of drugs. The animals treated with ketamine-perampanel combination demonstrated improved exploratory behavior in OFT (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/3193725