Preliminary national report on cystic fibrosis epidemiology in Tunisia: the actual state of affairs

To establish a preliminary national report on clinical and genetic features of cystic fibrosis (CF) in Tunisian children as a first measure for a better health care organization. All children with CF diagnosed by positive sweat tests between 1996 and 2015 in children's departments of Tunisian u...

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Published in:African health sciences 2020-03, Vol.20 (1), p.444-452
Main Authors: Hamouda, Samia, Fredj, Sondess Hadj, Hilioui, Sonia, Khalsi, Fatma, Ameur, Salma Ben, Bouguila, Jihene, Boussoffara, Raoudha, Besbes, Habib, Ajmi, Houda, Mattoussi, Nadia, Messaoud, Taieb, Mehrezi, Ahmed, Hachicha, Mongia, Boughamoura, Lamia, Sfar, Mohamed Taher, Gueddiche, Neji, Abroug, Saoussen, Becheur, Saida Ben, Barsaoui, Sihem, Tebib, Neji, Samoud, Azza, Gandoura, Najoua, Tinsa, Faten, Boussetta, Khadija
Format: Article
Language:English
Subjects:
Child
Cystic Fibrosis - complications
Cystic Fibrosis - epidemiology
Diarrhea - etiology
Female
Humans
Infant
Male
Malnutrition - etiology
Respiratory Tract Infections - complications
Respiratory Tract Infections - etiology
Retrospective Studies
Tunisia - epidemiology
Young Adult
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Summary:To establish a preliminary national report on clinical and genetic features of cystic fibrosis (CF) in Tunisian children as a first measure for a better health care organization. All children with CF diagnosed by positive sweat tests between 1996 and 2015 in children's departments of Tunisian university hospitals were included. Data was recorded at diagnosis and during the follow-up from patients' medical records. In 12 departments, 123 CF children were collected. The median age at diagnosis was 5 months with a median diagnosis delay of 3 months. CF was revealed mostly by recurrent respiratory tract infections (69.9%), denutrition (55.2%), and/or chronic diarrhea (41.4%). The mean sweat chloride concentration was 110.9mmol/L. At least one mutation was found in 95 cases (77.2%). The most frequent mutations were Phe508del (n=58) and E1104X (n=15). Fifty-five patients had a chronic colonization at a median age of 30 months. Cirrhosis and diabetes appeared at a mean age of 5.5 and 12.5 years respectively in 4 patients each. Sixty-two patients died at a median age of 8 months. Phe508del mutation and hypotrophy were associated with death (p=0.002 and p
ISSN:1680-6905
1729-0503
1680-6905
DOI:10.4314/ahs.v20i1.51