Comparison of nanoemulsion and non-emollient artificial tears on tear lipid layer thickness and symptoms

Dry eye disease (DED) is often managed with over-the-counter eye drops. This study evaluated the diurnal effects of a single drop of two ocular lubricants (nanoemulsion vs. non-emollient) on tear film lipid layer thickness (LLT) and symptoms of ocular dryness. Subjects were also assessed after 1 mon...

Full description

Saved in:
Bibliographic Details
Published in:Journal of optometry 2021-01, Vol.14 (1), p.20-27
Main Authors: Weisenberger, Kimberly, Fogt, Nick, Swingle Fogt, Jennifer
Format: Article
Language:English
Subjects:
Artificial tears
Dry eye disease
Eye drops
Gotas oftálmicas
Grosor de la capa lipídica
Lipid layer thickness
Lágrimas artificiales
Original
Síndrome del ojo seco
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dry eye disease (DED) is often managed with over-the-counter eye drops. This study evaluated the diurnal effects of a single drop of two ocular lubricants (nanoemulsion vs. non-emollient) on tear film lipid layer thickness (LLT) and symptoms of ocular dryness. Subjects were also assessed after 1 month of nanoemulsion eye drop use. Part 1 was a cross-over comparison of a nanoemulsion and a non-emollient eye drop. LLT and dry eye symptoms were measured at baseline and at 15min, 1h, 2h, 4h and 6h after instillation of each drop. Part 2 was a 1-month observational study assessing LLT and symptoms after 30-day use of the nanoemulsion drop four times daily (qid). Total of 20 subjects completed the study (mean age=45.6±7.9, 15 female). Part 1 found a significant increase in average LLT 15min after nanoemulsion drop instillation in the overall and inferior third of the tear film for subjects with baseline LLT values
ISSN:1888-4296
1989-1342
DOI:10.1016/j.optom.2020.03.002