Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1

• Published in: Journal of cellular and molecular medicine 2020-12, Vol.24 (23), p.14039-14049
• Main Authors: Guan, Jingqian, Jiang, Xizi, Gai, Junda, Sun, Xiaodan, Zhao, Jinming, Li, Ji, Li, Yizhuo, Cheng, Ming, Du, Tengjiao, Fu, Lin, Li, Qingchang
• Format: Article
• Language: English
• Subjects: ACAT1; Acetyl-CoA C-Acetyltransferase - metabolism; Acetyltransferase; Adult; Aged; Antibodies; Cell culture; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell Proliferation; Cyclin D1; Diagnosis; Gelatinase B; Gene Expression; Gene Expression Regulation, Neoplastic; Gleason score; Humans; Immunohistochemistry; Kinases; Male; MAP kinase; MAP Kinase Signaling System; MAPK signalling pathway; Mass spectroscopy; Medical diagnosis; Medical prognosis; Middle Aged; NAD; Neoplasm Grading; Original; Prostate cancer; Prostatic Neoplasms - etiology; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Protein Binding; Protein kinase; Proteins; Sirtuin 5; Sirtuins - genetics; Sirtuins - metabolism
• ISSN: 1582-1838; 1582-4934
• DOI: 10.1111/jcmm.16016

Sirtuin 5 (SIRT5) is a NAD+‐dependent class III protein deacetylase, and its role in prostate cancer has not yet been reported. Therefore, to explore the diagnosis and treatment of prostate cancer, we investigated the effect of SIRT5 on prostate cancer. Sirtuin 5 was assessed by immunohistochemistry in 57 normal and cancerous prostate tissues. We found that the tissue expression levels of SIRT5 in patients with Gleason scores ≥7 were significantly different from those in patients with Gleason scores