Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction

• Published in: NMR in biomedicine 2019-02, Vol.32 (2), p.e4041-n/a
• Main Authors: Hamilton, Jesse I., Jiang, Yun, Ma, Dan, Chen, Yong, Lo, Wei‐Ching, Griswold, Mark, Seiberlich, Nicole
• Format: Article
• Language: English
• Subjects: Acceleration; Biological products; Computer Simulation; Fingerprinting; Heart; Heart - diagnostic imaging; Humans; Image Processing, Computer-Assisted; Image reconstruction; In vivo methods and tests; Linear Models; low rank; Magnetic resonance; magnetic resonance fingerprinting; Magnetic Resonance Imaging; Mapping; parameter mapping; Phantoms, Imaging; relaxation times; Resonance; Schedules; Signal Processing, Computer-Assisted; simultaneous multislice; spiral
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.4041

This study introduces a technique for simultaneous multislice (SMS) cardiac magnetic resonance fingerprinting (cMRF), which improves the slice coverage when quantifying myocardial T1, T2, and M0. The single‐slice cMRF pulse sequence was modified to use multiband (MB) RF pulses for SMS imaging. Different RF phase schedules were used to excite each slice, similar to POMP or CAIPIRINHA, which imparts tissues with a distinguishable and slice‐specific magnetization evolution over time. Because of the high net acceleration factor (R = 48 in plane combined with the slice acceleration), images were first reconstructed with a low rank technique before matching data to a dictionary of signal timecourses generated by a Bloch equation simulation. The proposed method was tested in simulations with a numerical relaxation phantom. Phantom and in vivo cardiac scans of 10 healthy volunteers were also performed at 3 T. With single‐slice acquisitions, the mean relaxation times obtained using the low rank cMRF reconstruction agree with reference values. The low rank method improves the precision in T1 and T2 for both single‐slice and SMS cMRF, and it enables the acquisition of maps with fewer artifacts when using SMS cMRF at higher MB factors. With this technique, in vivo cardiac maps were acquired from three slices simultaneously during a breathhold lasting 16 heartbeats. SMS cMRF improves the efficiency and slice coverage of myocardial T1 and T2 mapping compared with both single‐slice cMRF and conventional cardiac mapping sequences. Thus, this technique is a first step toward whole‐heart simultaneous T1 and T2 quantification with cMRF. Cardiac magnetic resonance fingerprinting was modified for simultaneous multislice acquisitions. The sequence employs multiband RF pulses with a different RF phase schedule applied to each slice. When combined with a low rank reconstruction, simultaneous T1, T2, and M0 maps from three slices can be acquired in vivo during one breathhold.