Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease‐free survival

Background This study aimed to explore the clinical implications of katanin P60 and P80 (katanin P60/P80) regarding their correlations with clinicopathological features and survival profiles in papillary thyroid carcinoma (PTC) patients. Methods Tumor tissue and paired adjacent tissue specimens were...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical laboratory analysis 2020-12, Vol.34 (12), p.e23502-n/a
Main Authors: Chen, Qinggui, Lin, Fusheng, Lin, Ende, Huang, Qinghe, Wu, Guoyang
Format: Article
Language:English
Subjects:
Age
Biomarkers
Breast cancer
Cancer therapies
Cell adhesion & migration
Cell division
Gender
Hospitals
Immunohistochemistry
Iodine
katanin P60
katanin P80
Lung cancer
Lymphatic system
Medical prognosis
Metastasis
Papillary thyroid carcinoma
prognosis
Prostate cancer
Software
Survival
Thyroid
Thyroid cancer
Thyroidectomy
tumor stage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background This study aimed to explore the clinical implications of katanin P60 and P80 (katanin P60/P80) regarding their correlations with clinicopathological features and survival profiles in papillary thyroid carcinoma (PTC) patients. Methods Tumor tissue and paired adjacent tissue specimens were obtained from 172 PTC patients who underwent lobectomy or thyroidectomy. Besides, immunohistochemistry assay and immunoreactive (IR) score (multiplying staining intensity score by density score) were used to determine katanin P60/P80 expressions. According to IR score (from 0 ~ 12), katanin P60/P80 expressions were classified as low (IR score 0 ~ 3) and high (IR score 4 ~ 12) expressions. Results Both katanin P60/P80 expressions were highly expressed in tumor tissue compared with adjacent tissue. Besides, tumor katanin P60 expression positively correlated with tumor katanin P80 expression. Tumor katanin P60 high expression correlated with larger tumor size, extrathyroidal invasion, advanced pT stage, pN stage, and pTNM stage, while no correlation of tumor katanin P60 expression with age or gender was observed; tumor katanin P80 high expression correlated with advanced pN stage and pTNM stage, whereas there was no correlation of tumor katanin P80 expression with age, gender, tumor size, extrathyroidal invasion, or pT stage. Furthermore, both tumor katanin P60/P80 high expressions correlated with shorter accumulating disease‐free survival. As for overall survival (OS), neither tumor katanin P60 nor P80 expression correlated with OS. Conclusion Katanin P60/P80 measurement might assist with tumor management and prognosis surveillance in PTC patients.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.23502