Prospective performance of clear cell likelihood scores (ccLS) in renal masses evaluated with multiparametric magnetic resonance imaging

Objectives Solid renal masses have unknown malignant potential with commonly utilized imaging. Biopsy can offer a diagnosis of cancer but has a high non-diagnostic rate and complications. Reported use of multiparametric magnetic resonance imaging (mpMRI) to diagnose aggressive histology (i.e., clear...

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Bibliographic Details
Published in:European radiology 2021-01, Vol.31 (1), p.314-324
Main Authors: Steinberg, Ryan L., Rasmussen, Robert G., Johnson, Brett A., Ghandour, Rashed, De Leon, Alberto Diaz, Xi, Yin, Yokoo, Takeshi, Kim, Sandy, Kapur, Payal, Cadeddu, Jeffrey A., Pedrosa, Ivan
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Carcinoma, Renal Cell - diagnostic imaging
Clear cell-type renal cell carcinoma
Clinical decision making
Complications
Contingency
Decision making
Diagnosis
Diagnostic Radiology
Diagnostic systems
Histology
Humans
Imaging
Independent variables
Institutions
Internal Medicine
Interventional Radiology
Kidney cancer
Kidney Neoplasms - diagnostic imaging
Magnetic Resonance Imaging
Male
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Morbidity
Multiparametric Magnetic Resonance Imaging
Neuroradiology
Prospective Studies
Prostatic Neoplasms
Radiology
Regression analysis
Resonance
Retrospective Studies
Risk analysis
Risk factors
Statistical analysis
Tumors
Ultrasound
Urogenital
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Summary:Objectives Solid renal masses have unknown malignant potential with commonly utilized imaging. Biopsy can offer a diagnosis of cancer but has a high non-diagnostic rate and complications. Reported use of multiparametric magnetic resonance imaging (mpMRI) to diagnose aggressive histology (i.e., clear cell renal cell carcinoma (ccRCC)) via a clear cell likelihood score (ccLS) was based on retrospective review of cT1a tumors. We aim to retrospectively assess the diagnostic performance of ccLS prospectively assigned to renal masses of all stages evaluated with mpMRI prior to histopathologic evaluation. Methods In this retrospective cohort study from June 2016 to November 2019, 434 patients with 454 renal masses from 2 institutions with heterogenous patient populations underwent mpMRI with prospective ccLS assignment and had pathologic diagnosis. ccLS performance was assessed by contingency table analysis. The association between ccLS and ccRCC was assessed with logistic regression. Results Mean age and tumor size were 60 ± 13 years and 5.4 ± 3.8 cm. Characteristics were similar between institutions except for patient age and race (both p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-020-07093-0