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Retinal microvasculature impairment in patients with congenital heart disease investigated by optical coherence tomography angiography

Importance A high prevalence of retinal abnormalities have been reported in congenital heart disease (CHD), but quantitative analysis of retinal vasculature is scarce. Optical coherence tomography angiography (OCTA) is a noninvasive method to quantitatively assess the retinal microvasculature. Backg...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2020-12, Vol.48 (9), p.1219-1228
Main Authors: Li, Cong, Zhong, Pingting, Yuan, Haiyun, Dong, Xinran, Peng, Qingsheng, Huang, Manqing, Wu, Qiaowei, Liu, Baoyi, Xu, Minghui, Kuang, Yu, Zeng, Xiaomin, Xiao, Yu, Fang, Ying, Yu, Honghua, Yang, Xiaohong
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Language:English
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Summary:Importance A high prevalence of retinal abnormalities have been reported in congenital heart disease (CHD), but quantitative analysis of retinal vasculature is scarce. Optical coherence tomography angiography (OCTA) is a noninvasive method to quantitatively assess the retinal microvasculature. Background To investigate the retinal microvasculature changes in CHD patients by using OCTA. Design Cross‐sectional study. Participants A total of 158 participants including 57 cyanotic CHD (CCHD) patients, 60 acyanotic CHD (ACHD) patients and 41 control subjects were included. Methods All participants underwent a comprehensive ophthalmologic examination, including refraction measurement, intraocular pressure measurement and OCTA. Main Outcome Measures Vessel density (VD) was measured within the radial peripapillary capillary (RPC), superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula. Results CCHD patients had significantly lower VD in the RPC, SCP and DCP (all P 
ISSN:1442-6404
1442-9071
DOI:10.1111/ceo.13846