Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity—A PREVIEW randomized clinical trial

Summary Background Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of I...

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Published in:Pediatric obesity 2021-01, Vol.16 (1), p.e12702-n/a
Main Authors: Dorenbos, Elke, Drummen, Mathijs, Adam, Tanja, Rijks, Jesse, Winkens, Bjorn, Martínez, J. Alfredo, Navas‐Carretero, Santiago, Stratton, Gareth, Swindell, Nils, Stouthart, Pauline, Mackintosh, Kelly, Mcnarry, Melitta, Tremblay, Angelo, Fogelholm, Mikael, Raben, Anne, Westerterp‐Plantenga, Margriet, Vreugdenhil, Anita
Format: Article
Language:English
Subjects:
Adolescent
Childrens health
Clinical trials
Diet
Diet, High-Protein - methods
dietary protein
Exercise
Female
Follow-Up Studies
glycaemic index
glycaemic load
Glycemic Index
Humans
Insulin Resistance
Male
Obesity
Original Research
Overweight
Patient Compliance
Pediatric Obesity - diet therapy
Pediatric Obesity - physiopathology
Pediatrics
physical activity
Proteins
pubertal insulin resistance
Teenagers
Treatment Outcome
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Summary:Summary Background Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA‐IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity. Methods Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI 
ISSN:2047-6302
2047-6310
DOI:10.1111/ijpo.12702