Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects

Introduction: Nowadays, hair loss is becoming a major problem for a large number of people. The main factors affecting hair growth include racial, gender, genetics, and hormonal. Furthermore, environment, physiology, and nutrition are the tools that are affecting hair growth. Materials and Methods:...

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Bibliographic Details
Published in:International journal of trichology 2020-07, Vol.12 (4), p.168-175
Main Authors: Ashtiani, Hamid, Dadgar, Asma, Akaberi, Melika
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Ascorbic acid
Cell growth
EDTA
Follicles
Hair
Nitric oxide
Nutrition
Original
Oxidizing agents
Papillae
Physiological aspects
Reactive oxygen species
Stimulation
Vitamin C
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Summary:Introduction: Nowadays, hair loss is becoming a major problem for a large number of people. The main factors affecting hair growth include racial, gender, genetics, and hormonal. Furthermore, environment, physiology, and nutrition are the tools that are affecting hair growth. Materials and Methods: This article analyses the effects of silymarin and Vitamin C on the proliferation of dermal papilla cells (DPCs), COX2, inducible nitric oxide synthase (iNOS), total anti-oxidant capacity (TAC), and reactive oxygen species (ROS). The DPCs of the hair follicle treated by 50 and 100 μM of silymarin and 100 μM of Vitamin C on days 2, 7, and 14. Results: A comparatively effect of silymarin and Vitamin C demonstrated that Vitamin C is more effective in the stimulation of dermal papillae in cell culture. Furthermore, the stimulation effects of silymarin are attributed to its antioxidant activity of the cells. Conclusion: The overall result shows that cell proliferation and TAC significantly increased. However, iNOS, ROS, and COX2 levels were decreased.
ISSN:0974-7753
0974-9241
DOI:10.4103/ijt.ijt_124_19