The Influence of Systemic Inflammation Response Index on Survival Outcomes of Limited-Stage Small-Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy

Background. Recent studies have indicated that the systemic inflammation response index (SIRI) can efficiently predict survival outcomes in various tumor types. Thusly, in absence of comparable investigations in limited-stage small-cell lung cancers (LS-SCLCs), we aimed to retrospectively evaluate t...

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Bibliographic Details
Published in:Journal of oncology 2020, Vol.2020 (2020), p.1-8
Main Authors: Topkan, Erkan, Pehlivan, Berrin, Mertsoylu, Huseyin, Eskici Oztep, Sukran, Ozkan, Emine Elif, Kucuk, Ahmet, Selek, Ugur
Format: Article
Language:English
Subjects:
Age
Anemia
Blood tests
Cancer therapies
Care and treatment
Chemotherapy
Inflammation
Lung cancer
Lymphocytes
Magnetic resonance imaging
Males
Medical imaging
Medical prognosis
Metastasis
Neurological disorders
Neutrophils
Oncology
Patient outcomes
Patients
Prognosis
Radiation therapy
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Summary:Background. Recent studies have indicated that the systemic inflammation response index (SIRI) can efficiently predict survival outcomes in various tumor types. Thusly, in absence of comparable investigations in limited-stage small-cell lung cancers (LS-SCLCs), we aimed to retrospectively evaluate the prognostic utility of SIRI in LS-SCLC patients treated with concurrent chemoradiotherapy (CRT). Patients and Methods. Present multi-institutional retrospective analysis incorporated LS-SCLC patients treated with CRT at three academic radiation oncology centers between January 2007 and December 2018. The SIRI was calculated by using the peripheral blood neutrophil (N), monocyte (M), and lymphocyte (L) counts acquired in the last ≤7 days before the commencement of the CRT: SIRI = N × M/L. Accessibility of pretreatment SIRI cutoff that may stratify the study population into two gatherings with distinctive overall survival (OS) results was evaluated by utilizing the receiver operating characteristic (ROC) curve analysis. Primary objective was the association between the SIRI values and the OS results. Results. Search for the availability of an ideal SIRI cutoff that may stratify the entire patients’ population into two particular groups with distinctive OS outcomes identified the 1.93 value (area under the curve (AUC): 72.9%; sensitivity: 74.6%; specificity: 70.1%): Group 1: SIRI
ISSN:1687-8450
1687-8450
1687-8469
DOI:10.1155/2020/8832145