MiR-10a , 27a , 34b/c , and 300 Polymorphisms are Associated with Ischemic Stroke Susceptibility and Post-Stroke Mortality

A recent study of the ischemic stroke described the roles played by miRNAs in the downregulation of specific cell-cycle gene expression and it is thought to require the development of biomarkers for the prognostic of ischemic stroke. Here, we hypothesized that four miRNA polymorphisms ( , , /c, and...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2020-11, Vol.10 (12), p.309
Main Authors: Ryu, Chang Soo, Oh, Seung Hun, Lee, Kee Ook, Park, Han Sung, An, Hui Jeong, Lee, Jeong Yong, Ko, Eun Ju, Park, Hyeon Woo, Kim, Ok Joon, Kim, Nam Keun
Format: Article
Language:English
Subjects:
Age
Biomarkers
Disease
Gene expression
Gene polymorphism
Health risks
Ischemia
Magnetic resonance imaging
Medical prognosis
miRNA
Mortality
Pathogenesis
Patients
Polymerase chain reaction
Polymorphism
Regression analysis
Regression models
Restriction fragment length polymorphism
Stroke
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Summary:A recent study of the ischemic stroke described the roles played by miRNAs in the downregulation of specific cell-cycle gene expression and it is thought to require the development of biomarkers for the prognostic of ischemic stroke. Here, we hypothesized that four miRNA polymorphisms ( , , /c, and ) may affect stroke susceptibility and mortality. Blood samples were collected from 530 patients and 403 controls. Genetic polymorphisms were detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and real-time PCR. We found that the rs12894467 TC genotype and the dominant model (AOR: 2.069, -value: 0.017; AOR: 1.931, -value: 0.027) were significantly associated with an increased risk for the ischemic stroke subtype. In Cox proportional hazard regression models, the rs3809783 A>T and rs4938723 T>C polymorphisms were associated with the mortality rates among ischemic stroke patients. We found that a polymorphism was associated with increased ischemic stroke susceptibility among the Korean population. Additionally, polymorphisms in and were associated with the increased or decreased mortality of ischemic stroke patients. This study marks the first report of an association between ischemic stroke and miRNA polymorphisms ( A>T, - T>C, T>C, and T>C) in the Korean population.
ISSN:2075-1729
2075-1729
DOI:10.3390/life10120309