Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem

Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterin...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-11, Vol.9 (12), p.3870
Main Authors: Jabłoński, Krzysztof, Kurek, Łukasz, Żukowski, Maciej, Data-Jabłońska, Natalia, Żukowska, Karolina, Milewska, Anna J, Lipka, Aleksandra, Jóźwik, Marcin
Format: Article
Language:English
Subjects:
Asymptomatic
Breast cancer
Cancer therapies
Clinical medicine
Disease
Endometrial cancer
Endometrium
Estrogens
Females
Gynecology
Hyperplasia
Industrialized nations
Medical screening
Medicine
Mortality
Patients
Sarcoma
Ultrasonic imaging
Uterine cancer
Uterus
Womens health
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Summary:Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium-endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography ( < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9123870