Metabolomic Profiles Predict Diabetes Remission after Bariatric Surgery

Amino acid metabolites (AAMs) have been linked to glucose homeostasis and type 2 diabetes (T2D). We investigated whether (1) baseline AAMs predict T2D remission 12 months after bariatric surgery and (2) whether AAMs are superior for predicting T2D remission postoperatively compared with existing pre...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2020-12, Vol.9 (12), p.3897
Main Authors: Ha, Jane, Jang, Mi, Kwon, Yeongkeun, Park, Young Suk, Park, Do Joong, Lee, Joo-Ho, Lee, Hyuk-Joon, Ha, Tae Kyung, Kim, Yong-Jin, Han, Sang-Moon, Han, Sang-Uk, Heo, Yoonseok, Park, Sungsoo
Format: Article
Language:English
Subjects:
Amino acids
Clinical medicine
Diabetes
Education
Gastrointestinal surgery
Glucose
Hemoglobin
Homeostasis
Insulin
Metabolites
Nutrition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amino acid metabolites (AAMs) have been linked to glucose homeostasis and type 2 diabetes (T2D). We investigated whether (1) baseline AAMs predict T2D remission 12 months after bariatric surgery and (2) whether AAMs are superior for predicting T2D remission postoperatively compared with existing prediction models. Among 24 participants undergoing bariatric surgery, 16 diabetes-related AAMs were quantified at baseline and postoperative 3 and 12 months. Existing prediction models included the ABCD, DiaRem, and IMS models. Baseline L-dihydroxyphenylalanine (L-DOPA) (areas under receiver operating characteristic curves (AUROC), 0.92; 95% confidence interval (CI), 0.75 to 1.00) and 3-hydroxyanthranilic acid (3-HAA) (AUROC, 0.85; 95% CI, 0.67 to 1.00) better predicted T2D remission 12 months postoperatively than the ABCD model (AUROC, 0.81; 95% CI, 0.54 to 1.00), which presented the highest AUROC value among the three models. The superior prognostic performance of L-DOPA (AUROC at 3 months, 0.97; 95% CI, 0.91 to 1.00) and 3-HAA (AUROC at 3 months, 0.86; 95% CI, 0.63 to 1.00) continued until 3 months postoperatively. The AAM profile predicts T2D remission after bariatric surgery more effectively than the existing prediction models.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9123897