Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases

• Published in: Journal of clinical medicine 2020-11, Vol.9 (12), p.3800
• Main Authors: Garcia-Clemente, Marta, de la Rosa, David, Máiz, Luis, Girón, Rosa, Blanco, Marina, Olveira, Casilda, Canton, Rafael, Martinez-García, Miguel Angel
• Format: Article
• Language: English
• Subjects: Adaptation; Antibiotics; Antimicrobial agents; Asthma; Bacterial infections; Biofilms; Chronic obstructive pulmonary disease; Clinical medicine; Cloning; Cystic fibrosis; Genomes; Infections; Inflammation; Pathogens; Review; Virulence
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm9123800

( ) is a ubiquitous and opportunistic microorganism and is considered one of the most significant pathogens that produce chronic colonization and infection of the lower respiratory tract, especially in people with chronic inflammatory airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis. From a microbiological viewpoint, the presence and persistence of over time are characterized by adaptation within the host that precludes any rapid, devastating injury to the host. Moreover, this microorganism usually develops antibiotic resistance, which is accelerated in chronic infections especially in those situations where the frequent use of antimicrobials facilitates the selection of "hypermutator strain". This phenomenon has been observed in people with bronchiectasis, CF, and the "exacerbator" COPD phenotype. From a clinical point of view, a chronic bronchial infection of has been related to more severity and poor prognosis in people with CF, bronchiectasis, and probably in COPD, but little is known on the effect of this microorganism infection in people with asthma. The relationship between the impact and treatment of infection in people with airway diseases emerges as an important future challenge and it is the most important objective of this review.