Overexpression of LncRNA SNHG1 Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma

As the most prevalent type of head and neck cancer, oral squamous-cell carcinoma (OSCC) accounts for nearly 90% of all oral cancer cases. Despite great progress having been made in the diagnosis and treatment of OSCC recently, the survival rate of OSCC patients has not risen remarkably. Chemotherapy...

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Bibliographic Details
Published in:OncoTargets and therapy 2020-01, Vol.13, p.13033-13039
Main Authors: Wang, Xin, Yang, Song, Lv, Xuechao, Wang, Lina, Li, Chunmei
Format: Article
Language:English
Subjects:
Adenoviruses
Animal research
Antitumor activity
Biomarkers
Biotechnology
Bone cancer
Cancer therapies
Cell growth
Cell proliferation
Chemoresistance
Chemotherapy
Cisplatin
Ethics
Experiments
Head & neck cancer
Laboratory animals
Liver cancer
Metastasis
Molecular modelling
Oncolysis
Oral cancer
Original Research
Squamous cell carcinoma
Statistical analysis
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Summary:As the most prevalent type of head and neck cancer, oral squamous-cell carcinoma (OSCC) accounts for nearly 90% of all oral cancer cases. Despite great progress having been made in the diagnosis and treatment of OSCC recently, the survival rate of OSCC patients has not risen remarkably. Chemotherapy is commonly used for OSCC treatment; however, the emergence of chemoresistance limits its long-term curative effect. Therefore, identifying effective biomarkers and molecular mechanisms is essential to the development of therapeutic strategies for OSCC. qRT-PCR assays were performed to detect expression in OSCC tissue and cells, and CCK8 assays and animal experiments used to examine cell proliferation. In addition, CCK8 assays were used to detect IC values of cisplatin, 5Fu, Dox, and oncolytic adenovirus H101. We found that was overexpressed in OSCC tissue and cells and was associated with OSCC progression. In addition, knockdown of suppressed cell proliferation in vitro and in vivo. Importantly, we found that oncolytic adenovirus H101 showed better antitumor effects in OSCC with high expression, and chemotherapy showed worse anti-tumor effects in OSCC with high expression. can act as a diagnostic biomarker for OSCC, and may be a biomarker for treatment options.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S285536