CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing

The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-12, Vol.9 (12), p.4036
Main Authors: Aiello, Francesco, Gallo Afflitto, Gabriele, Li, Ji-Peng Olivia, Martucci, Alessio, Cesareo, Massimo, Nucci, Carlo
Format: Article
Language:English
Subjects:
Clinical medicine
Cornea
Endothelium
Eye diseases
Fibroblasts
Homeostasis
Inflammation
Kinases
Pain
Physiology
Review
Signal transduction
Wound healing
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Summary:The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the regulation of tissue repair and fibrosis, neo-angiogenesis and pain perception. This review aims to summarize all the available data on ECS expression and its function in ocular surface structures to provide a specific insight concerning its modulation in dry eye disease, and to propose directions for future research.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9124036